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Contrast-to-noise ratios and thickness-normalized, ventilation-dependent signal levels in dark-field and conventional in vivo thorax radiographs of two pigs

De Marco, Fabio; Willer, Konstantin; Gromann, Lukas B.; Andrejewski, Jana; Hellbach, Katharina; Bähr, Andrea; Dmochewitz, Michaela; Koehler, Thomas; Maack, Hanns-Ingo; Pfeiffer, Franz; Herzen, Julia


Lung tissue causes significant small-angle X-ray scattering, which can be visualized with grating-based X-ray dark-field imaging. Structural lung diseases alter alveolar microstructure, which often causes a dark-field signal decrease. The imaging method provides benefits for diagnosis of such diseases in small-animal models, and was successfully used on porcine and human lungs in a fringe-scanning setup. Micro- and macroscopic changes occur in the lung during breathing, but their individual effects on the dark-field signal are unknown. However, this information is important for quantitative medical evaluation of dark-field thorax radiographs. To estimate the effect of these changes on the dark-field signal during a clinical examination, we acquired in vivo dark-field chest radiographs of two pigs at three ventilation pressures. Pigs were used due to the high degree of similarity between porcine and human lungs. To analyze lung expansion separately, we acquired CT scans of both pigs at comparable posture and ventilation pressures. Segmentation, masking, and forward-projection of the CT datasets yielded maps of lung thickness and logarithmic lung attenuation signal in registration with the dark-field radiographs. ... mehr

Verlagsausgabe §
DOI: 10.5445/IR/1000137144
Veröffentlicht am 02.09.2021
DOI: 10.1371/journal.pone.0217858
Zitationen: 11
Web of Science
Zitationen: 10
Zitationen: 12
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Beschleunigerphysik und Technologie (IBPT)
Institut für Mikrostrukturtechnik (IMT)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2019
Sprache Englisch
Identifikator ISSN: 1932-6203
KITopen-ID: 1000137144
HGF-Programm 54.01.01 (POF III, LK 01) ps- und fs-Strahlen
Erschienen in PLOS ONE
Verlag Public Library of Science (PLoS)
Band 14
Heft 6
Seiten Art.-Nr.: e0217858
Vorab online veröffentlicht am 03.06.2019
Nachgewiesen in Web of Science
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