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Piezoelectric Silicon Micropump for Drug Delivery Applications

Bußmann, Agnes ORCID iD icon 1; Leistner, H.; Zhou, D.; Wackerle, M.; Congar, Y.; Richter, M.; Hubbuch, Jürgen ORCID iD icon 1
1 Institut für Bio- und Lebensmitteltechnik (BLT), Karlsruher Institut für Technologie (KIT)

Abstract:

Subcutaneous injection is crucial for the treatment of many diseases. Especially for regular or continuous injections, automated dosing is beneficial. However, existing devices are large, uncomfortable, visible under clothing, or interfere with physical activity. Thus, the development of small, energy efficient and reliable patch pumps or implantable systems is necessary and research on microelectromechanical system (MEMS) based drug delivery devices has gained increasing interest. However, the requirements of medical applications are challenging and especially the dosing precision and reliability of MEMS pumps are not yet sufficiently evaluated. To enable further miniaturization, we propose a precise 5 × 5 mm2 silicon micropump. Detailed experimental evaluation of ten pumps proves a backpressure capability with air of 12.5 ± 0.8 kPa, which indicates the ability to transport bubbles. The maximal water flow rate is 74 ± 6 µL/min and the pumps’ average blocking pressure is 51 kPa. The evaluation of the dosing precision for bolus deliveries with water and insulin shows a high repeatability of dosed package volumes. The pumps show a mean standard deviation of only 0.02 mg for 0.5 mg packages, and therefore, stay below the generally accepted 5% deviation, even for this extremely small amount. ... mehr


Verlagsausgabe §
DOI: 10.5445/IR/1000137576
Veröffentlicht am 24.09.2021
Originalveröffentlichung
DOI: 10.3390/app11178008
Scopus
Zitationen: 16
Web of Science
Zitationen: 13
Dimensions
Zitationen: 16
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Bio- und Lebensmitteltechnik (BLT)
Publikationstyp Zeitschriftenaufsatz
Publikationsmonat/-jahr 09.2021
Sprache Englisch
Identifikator ISSN: 2076-3417
KITopen-ID: 1000137576
Erschienen in Applied Sciences (Switzerland)
Verlag MDPI
Band 11
Heft 17
Seiten Art.-Nr.: 8008
Vorab online veröffentlicht am 30.08.2021
Nachgewiesen in Scopus
Dimensions
Web of Science
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