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Period 2: A Regulator of Multiple Tissue-Specific Circadian Functions

Ruggiero, Gennaro 1; Ben-Moshe Livne, Zohar; Wexler, Yair; Geyer, Nathalie 1; Vallone, Daniela 1; Gothilf, Yoav; Foulkes, Nicholas S. 1
1 Institut für Biologische und Chemische Systeme (IBCS), Karlsruher Institut für Technologie (KIT)


The zebrafish represents a powerful model for exploring how light regulates the circadian clock due to the direct light sensitivity of its peripheral clocks, a property that is retained even in organ cultures as well as zebrafish-derived cell lines. Light-inducible expression of the per2 clock gene has been predicted to play a vital function in relaying light information to the core circadian clock mechanism in many organisms, including zebrafish. To directly test the contribution of per2 to circadian clock function in zebrafish, we have generated a loss-of-function per2 gene mutation. Our results reveal a tissue-specific role for the per2 gene in maintaining rhythmic expression of circadian clock genes, as well as clock-controlled genes, and an impact on the rhythmic behavior of intact zebrafish larvae. Furthermore, we demonstrate that disruption of the per2 gene impacts on the circadian regulation of the cell cycle in vivo. Based on these results, we hypothesize that in addition to serving as a central element of the light input pathway to the circadian clock, per2 acts as circadian regulator of tissue-specific physiological functions in zebrafish.

Verlagsausgabe §
DOI: 10.5445/IR/1000138033
Veröffentlicht am 01.10.2021
DOI: 10.3389/fnmol.2021.718387
Zitationen: 3
Web of Science
Zitationen: 3
Zitationen: 3
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Biologische und Chemische Systeme (IBCS)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2021
Sprache Englisch
Identifikator ISSN: 1662-5099
KITopen-ID: 1000138033
HGF-Programm 47.14.02 (POF IV, LK 01) Information Storage and Processing in the Cell Nucleus
Erschienen in Frontiers in Molecular Neuroscience
Verlag Frontiers Media SA
Band 14
Seiten Art.Nr. 718387
Vorab online veröffentlicht am 03.09.2021
Nachgewiesen in Scopus
Web of Science
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