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Oxidative stress response in pseudomonas aeruginosa

Cruz Nizer, Waleska Stephanie da; Inkovskiy, Vasily; Versey, Zoya; Strempel, Nikola 1; Cassol, Edana; Overhage, Joerg
1 Institut für Funktionelle Grenzflächen (IFG), Karlsruher Institut für Technologie (KIT)


Pseudomonas aeruginosa is a Gram-negative environmental and human opportunistic pathogen highly adapted to many different environmental conditions. It can cause a wide range of serious infections, including wounds, lungs, the urinary tract, and systemic infections. The high versatility and pathogenicity of this bacterium is attributed to its genomic complexity, the expression of several virulence factors, and its intrinsic resistance to various antimicrobials. However, to thrive and establish infection, P. aeruginosa must overcome several barriers. One of these barriers is the presence of oxidizing agents (e.g., hydrogen peroxide, superoxide, and hypochlorous acid) produced by the host immune system or that are commonly used as disinfectants in a variety of different environments including hospitals. These agents damage several cellular molecules and can cause cell death. Therefore, bacteria adapt to these harsh conditions by altering gene expression and eliciting several stress responses to survive under oxidative stress. Here, we used PubMed to evaluate the current knowledge on the oxidative stress responses adopted by P. aeruginosa. ... mehr

Verlagsausgabe §
DOI: 10.5445/IR/1000138681
Veröffentlicht am 06.10.2021
DOI: 10.3390/pathogens10091187
Zitationen: 12
Web of Science
Zitationen: 9
Zitationen: 16
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Funktionelle Grenzflächen (IFG)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2021
Sprache Englisch
Identifikator ISSN: 2076-0817
KITopen-ID: 1000138681
HGF-Programm 43.33.11 (POF IV, LK 01) Adaptive and Bioinstructive Materials Systems
Erschienen in Pathogens
Verlag MDPI
Band 10
Heft 9
Seiten 1187
Schlagwörter Pseudomonas aeruginosa; oxidative stress; oxidative stress response; reactive oxygen species; reactive chlorine species; antimicrobial resistance; bacterial stress response
Nachgewiesen in Web of Science
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