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Fluorescent Nanozeolite Receptors for the Highly Selective and Sensitive Detection of Neurotransmitters in Water and Biofluids

Grimm, L. M. 1; Sinn, S. 1; Krstić, M. 1; D’Este, E.; Sonntag, I.; Prasetyanto, E. A.; Kuner, T. 2; Wenzel, W. 1; De Cola, L. 1; Biedermann, F. 1,2
1 Institut für Nanotechnologie (INT), Karlsruher Institut für Technologie (KIT)
2 Heidelberg Karlsruhe Strategic Partnership (HEiKA), Karlsruher Institut für Technologie (KIT)


The design and preparation of synthetic binders (SBs) applicable for small biomolecule sensing in aqueous media remains very challenging. SBs designed by the lock-and-key principle can be selective for their target analyte but usually show an insufficient binding strength in water. In contrast, SBs based on symmetric macrocycles with a hydrophobic cavity can display high binding affinities but generally suffer from indiscriminate binding of many analytes. Herein, a completely new and modular receptor design strategy based on microporous hybrid materials is presented yielding zeolite-based artificial receptors (ZARs) which reversibly bind the neurotransmitters serotonin and dopamine with unprecedented affinity and selectivity even in saline biofluids. ZARs are thought to uniquely exploit both the non-classical hydrophobic effect and direct non-covalent recognition motifs, which is supported by in-depth photophysical, and calorimetric experiments combined with full atomistic modeling. ZARs are thermally and chemically robust and can be readily prepared at gram scales. Their applicability for the label-free monitoring of important enzymatic reactions, for (two-photon) fluorescence imaging, and for high-throughput diagnostics in biofluids is demonstrated. ... mehr

Verlagsausgabe §
DOI: 10.5445/IR/1000138689
Veröffentlicht am 06.10.2021
DOI: 10.1002/adma.202104614
Zitationen: 12
Web of Science
Zitationen: 12
Zitationen: 12
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Nanotechnologie (INT)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2021
Sprache Englisch
Identifikator ISSN: 0935-9648, 1521-4095
KITopen-ID: 1000138689
HGF-Programm 43.32.01 (POF IV, LK 01) Molecular Materials Basis for Optics & Photonics
Erschienen in Advanced Materials
Verlag John Wiley and Sons
Band 33
Heft 49
Seiten Art.-Nr.: 2104614
Nachgewiesen in Scopus
Web of Science
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