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Neuron-Radial Glial Cell Communication via BMP/Id1 Signaling Is Key to Long-Term Maintenance of the Regenerative Capacity of the Adult Zebrafish Telencephalon

Zhang, Gaoqun; Lübke, Luisa; Chen, Fushun; Beil, Tanja; Takamiya, Masanari; Diotel, Nicolas; Strähle, Uwe; Rastegar, Sepand

Abstract:
The central nervous system of adult zebrafish displays an extraordinary neurogenic and regenerative capacity. In the zebrafish adult brain, this regenerative capacity relies on neural stem cells (NSCs) and the careful management of the NSC pool. However, the mechanisms controlling NSC pool maintenance are not yet fully understood. Recently, Bone Morphogenetic Proteins (BMPs) and their downstream effector Id1 (Inhibitor of differentiation 1) were suggested to act as key players in NSC maintenance under constitutive and regenerative conditions. Here, we further investigated the role of BMP/Id1 signaling in these processes, using different genetic and pharmacological approaches. Our data show that BMPs are mainly expressed by neurons in the adult telencephalon, while id1 is expressed in NSCs, suggesting a neuron-NSC communication via the BMP/Id1 signaling axis. Furthermore, manipulation of BMP signaling by conditionally inducing or repressing BMP signaling via heat-shock, lead to an increase or a decrease of id1 expression in the NSCs, respectively. Induction of id1 was followed by an increase in the number of quiescent NSCs, while knocking down id1 expression caused an increase in NSC proliferation. ... mehr


Verlagsausgabe §
DOI: 10.5445/IR/1000139566
Veröffentlicht am 02.11.2021
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Biologische und Chemische Systeme (IBCS)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2021
Sprache Englisch
Identifikator ISSN: 2073-4409
KITopen-ID: 1000139566
HGF-Programm 47.14.02 (POF IV, LK 01) Information Storage and Processing in the Cell Nucleus
Erschienen in Cells
Verlag MDPI
Band 10
Heft 10
Seiten Art.-Nr.: 2794
Vorab online veröffentlicht am 19.10.2021
Schlagwörter adult neurogenesis; regeneration; quiescence; telencephalon; radial glial cell; neural stem cell; BMP; id1; notch; her4.1; zebrafish
Nachgewiesen in Web of Science
Scopus
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