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Bio-instructive materials on-demand-combinatorial chemistry of peptoids, foldamers, and beyond

Herlan, Claudine Nicole; Feser, Dominik; Schepers, Ute; Bräse, Stefan

Abstract:
Combinatorial chemistry allows for the rapid synthesis of large compound libraries for high throughput screenings in biology, medicinal chemistry, or materials science. Especially compounds from a highly modular design are interesting for the proper investigation of structure-to-activity relationships. Permutations of building blocks result in many similar but unique compounds. The influence of certain structural features on the entire structure can then be monitored and serve as a starting point for the rational design of potent molecules for various applications. Peptoids, a highly diverse class of bioinspired oligomers, suit perfectly for combinatorial chemistry. Their straightforward synthesis on a solid support using repetitive reaction steps ensures easy handling and high throughput. Applying this modular approach, peptoids are readily accessible, and their interchangeable side-chains allow for various structures. Thus, peptoids can easily be tuned in their solubility, their spatial structure, and, consequently, their applicability in various fields of research. Since their discovery, peptoids have been applied as antimicrobial agents, artificial membranes, molecular transporters, and much more. ... mehr


Verlagsausgabe §
DOI: 10.5445/IR/1000139731
Veröffentlicht am 12.11.2021
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Biologische und Chemische Systeme (IBCS)
Institut für Funktionelle Grenzflächen (IFG)
Institut für Organische Chemie (IOC)
Publikationstyp Zeitschriftenaufsatz
Publikationsdatum 04.11.2021
Sprache Englisch
Identifikator ISSN: 1359-7345, 0009-241X, 0022-4936, 1364-548X, 2050-5620, 2050-5639
KITopen-ID: 1000139731
HGF-Programm 43.33.11 (POF IV, LK 01) Adaptive and Bioinstructive Materials Systems
Erschienen in Chemical Communications
Verlag Royal Society of Chemistry (RSC)
Band 57
Heft 85
Seiten 11131-11152
Vorab online veröffentlicht am 21.09.2021
Nachgewiesen in Web of Science
Scopus
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