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Association between inflammatory markers and serum paraoxonase and arylesterase activities in the general population: a cross-sectional study

Meisinger, Christa; Freuer, Dennis; Bub, Achim; Linseisen, Jakob

Abstract (englisch):
Background: Recent studies focused on modulating factors of paraoxonase-1 (PON1) activity. In some studies the association between pro-inflammatory markers and PON1 activity was examined, but so far no population-based investigations on this issue have been conducted. The present study investigated the relationships between the pro-inflammatory markers tumor necrosis factor (TNF)-α, leptin, interleukin (IL)-6, and high-sensitive C-reactive protein (hs-CRP) and paraoxonase and arylesterase, two hydrolytic activities of PON1, in the population-based Bavarian Food Consumption Survey II.

Methods: Based on 504 participants (217 men, 287 women), the relationship between the pro-inflammatory markers and the outcomes paraoxonase and arylesterase activities were investigated using multivariable linear models.

Results: Circulating plasma levels of leptin (P-value < 0.0001), hs-CRP (P-value = 0.031) and IL-6 (P-value = 0.045) were significantly non-linearly associated with arylesterase activity. Leptin levels were also significantly associated with paraoxonase activity (P-value = 0.024) independently from confounding factors, including high-density lipoprotein (HDL) cholesterol. ... mehr


Verlagsausgabe §
DOI: 10.5445/IR/1000140056
Veröffentlicht am 18.11.2021
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Sport und Sportwissenschaft (IfSS)
Publikationstyp Zeitschriftenaufsatz
Publikationsmonat/-jahr 12.2021
Sprache Englisch
Identifikator ISSN: 1476-511X
KITopen-ID: 1000140056
Erschienen in Lipids in health and disease
Verlag BioMed Central (BMC)
Band 20
Seiten Article no: 81
Vorab online veröffentlicht am 31.07.2021
Schlagwörter Arylesterase activity; Inflammation; Oxidative stress; PON1; Paraoxonase activity
Nachgewiesen in Web of Science
Scopus
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