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Selective excitation enables encoding and measurement of multiple diffusion parameters in a single experiment

MacKinnon, Neil; Alinaghian, Mehrdad; Silva, Pedro; Gloge, Thomas; Luy, Burkhard; Jouda, Mazin; Korvink, Jan G.

Abstract:
Band selectivity to address specific resonances in a spectrum enables one to encode individual settings for diffusion experiments. In a single experiment, this could include different gradient strengths (enabling coverage of a larger range of diffusion constants), different diffusion delays, or different gradient directions (enabling anisotropic diffusion measurement). In this report, a selective variant of the bipolar pulsed gradient eddy current delay (BPP-LED) experiment, enabling selective encoding of three resonances, was implemented. As proof of principle, the diffusion encoding gradient amplitude was assigned a range dependent on the selected signal, thereby allowing the extraction of the diffusion coefficient for water and a tripeptide (Met-Ala-Ser) with optimal settings in a single experiment.


Verlagsausgabe §
DOI: 10.5445/IR/1000140240
Veröffentlicht am 23.11.2021
Originalveröffentlichung
DOI: 10.5194/mr-2-835-2021
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Mikrostrukturtechnik (IMT)
Institut für Biologische Grenzflächen (IBG)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2021
Sprache Englisch
Identifikator ISSN: 2699-0016
KITopen-ID: 1000140240
HGF-Programm 43.35.02 (POF IV, LK 01) Functionality of Soft Matter and Biomolecular Systems
Erschienen in Magnetic resonance
Verlag Copernicus Publications
Band 2
Heft 2
Seiten 835–842
Vorab online veröffentlicht am 19.11.2021
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