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Microscale Interfacial Polymerization on a Chip

Rocca, Marco; Dufresne, Maxime; Salva, Marie; Niemeyer, Christof M. ORCID iD icon; Delamarche, Emmanuel


Forming hydrogels with precise geometries is challenging and mostly done using photopolymerization, which involves toxic chemicals, rinsing steps, solvents, and bulky optical equipment. Here, we introduce a new method for in situ formation of hydrogels with a well-defined geometry in a sealed microfluidic chip by interfacial polymerization. The geometry of the hydrogel is programmed by microfluidic design using capillary pinning structures and bringing into contact solutions containing hydrogel precursors from vicinal channels. The characteristics of the hydrogel (mesh size, molecular weight cut-off) can be readily adjusted. This method is compatible with capillary-driven microfluidics, fast, uses small volumes of reagents and samples, and does not require specific laboratory equipment. Our approach creates opportunities for filtration, hydrogel functionalization, and hydrogel-based assays, as exemplified by a rapid, compact competitive immunoassay that does not require a rinsing step.

Verlagsausgabe §
DOI: 10.5445/IR/1000140562
Veröffentlicht am 30.11.2021
DOI: 10.1002/anie.202110974
Zitationen: 4
Web of Science
Zitationen: 4
Zitationen: 5
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Biologische Grenzflächen (IBG)
Publikationstyp Zeitschriftenaufsatz
Publikationsdatum 02.11.2021
Sprache Englisch
Identifikator ISSN: 1433-7851, 1521-3773
KITopen-ID: 1000140562
HGF-Programm 43.33.11 (POF IV, LK 01) Adaptive and Bioinstructive Materials Systems
Erschienen in Angewandte Chemie / International edition
Verlag John Wiley and Sons
Band 60
Heft 45
Seiten 24064–24069
Vorab online veröffentlicht am 30.08.2021
Nachgewiesen in Scopus
Web of Science
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