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Microfluidic cell transport with piezoelectric micro diaphragm pumps

Bußmann, Agnes ORCID iD icon; Thalhofer, Thomas; Hoffmann, Sophie; Daum, Leopold; Surendran, Nivedha; Hayden, Oliver; Hubbuch, Jürgen ORCID iD icon; Richter, Martin


The automated transport of cells can enable far-reaching cell culture research. However, to date, such automated transport has been achieved with large pump systems that often come with long fluidic connections and a large power consumption. Improvement is possible with space- and energy-efficient piezoelectric micro diaphragm pumps, though a precondition for a successful use is to enable transport with little to no mechanical stress on the cell suspension. This study evaluates the impact of the microfluidic transport of cells with the piezoelectric micro diaphragm pump developed by our group. It includes the investigation of different actuation signals. Therewith, we aim to achieve optimal fluidic performance while maximizing the cell viability. The investigation of fluidic properties proves a similar performance with a hybrid actuation signal that is a rectangular waveform with sinusoidal flanks, compared to the fluidically optimal rectangular actuation. The comparison of the cell transport with three actuation signals, sinusoidal, rectangular, and hybrid actuation shows that the hybrid actuation causes less damage than the rectangular actuation. ... mehr

Verlagsausgabe §
DOI: 10.5445/IR/1000140886
Veröffentlicht am 08.12.2021
DOI: 10.3390/mi12121459
Zitationen: 10
Web of Science
Zitationen: 8
Zitationen: 10
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Bio- und Lebensmitteltechnik (BLT)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2021
Sprache Englisch
Identifikator ISSN: 2072-666X
KITopen-ID: 1000140886
Erschienen in Micromachines
Verlag MDPI
Band 12
Heft 12
Seiten 1459
Schlagwörter micro diaphragm pump; microfluidic; micro dosing; cell transport; automated cell culture; passive spring valves
Nachgewiesen in Dimensions
Web of Science
Globale Ziele für nachhaltige Entwicklung Ziel 7 – Bezahlbare und saubere Energie
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