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A longitudinal investigation of Aβ, anxiety, depression, and mild cognitive impairment

Pink, A.; Krell-Roesch, J.; Syrjanen, J. A.; Vassilaki, M.; Lowe, V. J.; Vemuri, P.; Stokin, G. B.; Christianson, T. J.; Kremers, W. K.; Jack, C. R.; Knopman, D. S.; Petersen, R. C.; Geda, Y. E.


We investigated the longitudinal relationship between cortical amyloid deposition, anxiety, and depression and the risk of incident mild cognitive impairment (MCI).

We followed 1440 community-dwelling, cognitively unimpaired individuals aged ≥ 50 years for a median of 5.5 years. Clinical anxiety and depression were assessed using Beck Anxiety and Depression Inventories (BAI, BDI-II). Cortical amyloid beta (Aβ) was measured by Pittsburgh compound B positron emission tomography (PiB-PET) and elevated deposition (PiB+) was defined as standardized uptake value ratio ≥ 1.48. We calculated Cox proportional hazards models with age as the time scale, adjusted for sex, education, and medical comorbidity.

Cortical Aβ deposition (PiB+) independent of anxiety (BAI ≥ 10) or depression (BDI-II ≥ 13) increased the risk of MCI. There was a significant additive interaction between PiB+ and anxiety (joint effect hazard ratio 6.77; 95% confidence interval 3.58–12.79; P = .031) that is, being PiB+ and having anxiety further amplified the risk of MCI.

Anxiety modified the association between PiB+ and incident MCI.

Verlagsausgabe §
DOI: 10.5445/IR/1000141121
Veröffentlicht am 15.12.2021
DOI: 10.1002/alz.12504
Zitationen: 5
Web of Science
Zitationen: 5
Zitationen: 8
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Sport und Sportwissenschaft (IfSS)
Publikationstyp Zeitschriftenaufsatz
Publikationsmonat/-jahr 10.2022
Sprache Englisch
Identifikator ISSN: 1552-5260, 1552-5279
KITopen-ID: 1000141121
Erschienen in Alzheimer’s and Dementia
Verlag John Wiley and Sons
Band 18
Heft 10
Seiten 1824-1831
Vorab online veröffentlicht am 08.12.2021
Nachgewiesen in Web of Science
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