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Oxidation of Dithia Compounds: Comparative Experimental and Theoretical Studies on 1,3 Bis(methylthio)propane, Bis(methylthio)methane, and Theoretical Studies on 1,3-Bis(methylthio)propane, Bis(methylthio)methane, and meso-4,6-Dimethyl-1,3-dithiane

Vallejos González, Victorino; Podlech, Joachim


1,3-Bis(methylthio)propane, bis(methylthio)methane, and meso-4,6-dimethyl-1,3-dithiane were oxidized with 1–4 equivalents of hydrogen peroxide, meta-chloroperbenzoic acid, sodium periodate, or potassium permanganate, respectively, and the amounts of oxidized substrates (sulfoxides and/or sulfones) were determined by NMR spectroscopy. Sulfanyl groups in the former starting material turned out to behave like independent functions, while a mutual influence of the sulfur functions was verified in the latter compounds. A meaningful investigation was possible in the conformationally constrained dithiane derivative. Oxidation of the dithiane with stoichiometric amounts of periodate led to exclusive formation of bissulfoxides, while hydrogen peroxide and meta-chloroperbenzoic acid yielded the possible products less specifically and permanganate preferentially furnished sulfones. The experimental investigations were supported by calculations on energies and stereoelectronic effects of starting materials, products, and transition states. The unique property of permanganate to exclusively yield sulfones might be due to its special oxidation mechanism, where the sulfur is not only acting as nucleophile, but concomitantly as electrophilic moiety.

Verlagsausgabe §
DOI: 10.5445/IR/1000141351
Veröffentlicht am 18.12.2021
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Organische Chemie (IOC)
Publikationstyp Zeitschriftenaufsatz
Publikationsmonat/-jahr 10.2021
Sprache Englisch
Identifikator ISSN: 1434-193X, 1099-0690
KITopen-ID: 1000141351
Erschienen in European journal of organic chemistry
Verlag John Wiley and Sons
Band 2021
Heft 39
Seiten 5430–5442
Vorab online veröffentlicht am 19.10.2021
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