Towards Quantitative ICG Angiography: Fluorescence Monte Carlo Multi Cylinder

Intraoperative blood flow measurement is an effective way to assess the quality of bypass surgery. Flow quantification from indocyanine green (ICG) angiography promises to be an easy, contact-free method. It shows deviations compared to areference. These are given as factor 𝑘, which dependson the vesseldiameter 𝑑. The radiation transport within the vessel while recording the ICG passage might cause this. It is analyzed in silicoto disclose its impact on 𝑘(𝑑). A Fluorescence Monte Carlo Multi Cylinder (FMCMC) model was developed as a static model, assuming homogeneous concentration of ICG. In contrast to published approaches utilizing a Monte Carlo MultiLayer (MCML) model assuming the deepest penetration location within a photon packet’s path to be the fluorescence location, the events aremodeled. Fluorescenceevent modeling, Multi Cylinder geometry and a homogeneous illumination as well as combinations of these were implemented in separate aspect models. Resulting 𝑘(𝑑)were compared to 𝑘(𝑑)from MCML. Deviations in 𝑘(𝑑)derived from FMCMC and MCML in each aspect model were present. The Root Mean Square Error ranges from 6,8% to 36 %, 𝑘(𝑑)also varied comparing the aspect models to each other. ... mehr The model geometry, the modeled fluorescence location and illumination mode show a clear impact on simulated 𝑘(𝑑). Therefore, our study shows that simplifications of previous studies are invalid.The developed FMCMC model considers the named aspects, allowing the analysis of radiation transport in ICG angiography. The FMCMC model assumes a homogeneous concentration of ICG which is not true in clinical cases. Obtaining the heterogeneous distributionof ICG is possible via fluid flow models. Coupling the fluid flow model and the developed radiation transport model as well as including a detailed camera optic is the task for future work