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In Vitro and In Vivo Toxicity Evaluation of Natural Products with Potential Applications as Biopesticides

Sangermano, Felicia; Masi, Marco; Kumar, Amrish; Peravali, Ravindra; Tuzi, Angela; Cimmino, Alessio; Vallone, Daniela; Giamundo, Giuliana; Conte, Ivan; Evidente, Antonio; Calabrò, Viola


The use of natural products in agriculture as pesticides has been strongly advocated. However, it is necessary to assess their toxicity to ensure their safe use. In the present study, mammalian cell lines and fish models of the zebrafish (Danio rerio) and medaka (Oryzias latipes) have been used to investigate the toxic effects of ten natural products which have potential applications as biopesticides. The fungal metabolites cavoxin, epi-epoformin, papyracillic acid, seiridin and sphaeropsidone, together with the plant compounds inuloxins A and C and ungeremine, showed no toxic effects in mammalian cells and zebrafish embryos. Conversely, cyclopaldic and α-costic acids, produced by Seiridium cupressi and Dittrichia viscosa, respectively, caused significant mortality in zebrafish and medaka embryos as a result of yolk coagulation. However, both compounds showed little effect in zebrafish or mammalian cell lines in culture, thus highlighting the importance of the fish embryotoxicity test in the assessment of environmental impact. Given the embryotoxicity of α-costic acid and cyclopaldic acid, their use as biopesticides is not recommended. ... mehr

Verlagsausgabe §
DOI: 10.5445/IR/1000142044
Veröffentlicht am 18.01.2022
DOI: 10.3390/toxins13110805
Zitationen: 5
Web of Science
Zitationen: 4
Zitationen: 5
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Biologische und Chemische Systeme (IBCS)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2021
Sprache Englisch
Identifikator ISSN: 2072-6651
KITopen-ID: 1000142044
HGF-Programm 47.14.02 (POF IV, LK 01) Information Storage and Processing in the Cell Nucleus
Erschienen in Toxins
Verlag MDPI
Band 13
Heft 11
Seiten Art. Nr.: 805
Vorab online veröffentlicht am 15.11.2021
Schlagwörter plant and microbial metabolites; cyclopaldic and α-costic acids; agricultural application; cytotoxicity; DNA damage; developmental toxicity; fish embryos
Nachgewiesen in Web of Science
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