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Towards Subject-Specific Therapy Planning for Non-Invasive Blood Brain Barrier Opening in Mice by Focused Ultrasound

Gross, Carl; Hopp, Torsten ORCID iD icon; Grudzenski-Theis, Saskia; Heger, Stefan; Fatar, Marc; Ruiter, Nicole V. ORCID iD icon

Abstract:

Focused ultrasound (FUS) is a promising method to open the blood brain barrier (BBB) for treatment of neurodegenerative diseases. Accurate targeting is essential for a successful BBB opening (BBBo). We aim to develop a robust therapy planning for BBBo in mice, which is challenging due to the size of the brain and the influence of the skull on the ultrasound pressure distribution. For enabling mouse individual therapy planning, a simulation tool is proposed, developed and validated. We used the k-Wave toolbox to enable 3D acoustic simulations of the commercial FUS system from Image Guided Therapy (IGT). ... mehr

Abstract (englisch):

Focused ultrasound (FUS) is a promising method to open the blood brain barrier (BBB) for treatment of neurodegenerative diseases. Accurate targeting is essential for a successful BBB opening (BBBo). We aim to develop a robust therapy planning for BBBo in mice, which is challenging due to the size of the brain and the influence of the skull on the ultrasound pressure distribution. For enabling mouse individual therapy planning, a simulation tool is proposed, developed and validated. We used the k-Wave toolbox to enable 3D acoustic simulations of the commercial FUS system from Image Guided Therapy (IGT). ... mehr


Postprint §
DOI: 10.5445/IR/1000142243
Veröffentlicht am 05.12.2022
Originalveröffentlichung
DOI: 10.1109/IUS52206.2021.9593545
Scopus
Zitationen: 1
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Zitationen: 1
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Prozessdatenverarbeitung und Elektronik (IPE)
Publikationstyp Proceedingsbeitrag
Publikationsmonat/-jahr 09.2021
Sprache Englisch
Identifikator ISBN: 978-1-66540-355-9
KITopen-ID: 1000142243
HGF-Programm 54.12.03 (POF IV, LK 01) Science Systems
Erschienen in 2021 IEEE International Ultrasonics Symposium (IUS)
Veranstaltung IEEE International Ultrasonics Symposium (IUS 2021), Online, 11.09.2021 – 16.09.2021
Verlag Institute of Electrical and Electronics Engineers (IEEE)
Seiten 1–4
Nachgewiesen in Scopus
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