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Rationale for Processing of a Mg-Zn-Ca Alloy by Equal-Channel Angular Pressing for Use in Biodegradable Implants for Osteoreconstruction

Martynenko, Natalia S.; Anisimova, Natalia Yu.; Rybalchenko, Olga V.; Kiselevskiy, Mikhail V.; Rybalchenko, Georgy; Straumal, Boris; Temralieva, Diana; Mansharipova, Almagul T.; Kabiyeva, Aigul O.; Gabdullin, Maratbek T.; Dobatkin, Sergey; Estrin, Yuri


Widespread use of Mg-Zn-Ca alloys in clinical orthopedic practice requires improvement of their mechanical properties—in particular, ductility—and enhancement of their bioactivity for accelerated osteoreconstruction. The alloy was studied in two structural states: after homogenization and after equal-channel angular pressing. Immersion and potentiodynamic polarization tests showed that the corrosion rate of the alloy was not increased by deformation. The mass loss in vivo was also statistically insignificant. Furthermore, it was found that deformation did not compromise the biocompatibility of the alloy and did not have any significant effect on cell adhesion and proliferation. However, an extract of the alloy promoted the alkaline phosphatase activity of human mesenchymal stromal cells, which indicates osteogenic stimulation of cells. The osteoinduction of the deformed alloy significantly exceeded that of the homogenized one. Based on the results of this work, it can be concluded that the alloy Mg-1%Zn-0.3%Ca modified by equal-channel angular pressing is a promising candidate for the manufacture of biodegradable orthopedic implants since it stimulates osteogenic differentiation and has greater ductility, which provides it with a competitive advantage in comparison with the homogenized state.

Verlagsausgabe §
DOI: 10.5445/IR/1000142546
Veröffentlicht am 28.01.2022
DOI: 10.3390/cryst11111381
Zitationen: 8
Zitationen: 9
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Nanotechnologie (INT)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2021
Sprache Englisch
Identifikator ISSN: 2073-4352
KITopen-ID: 1000142546
HGF-Programm 43.31.01 (POF IV, LK 01) Multifunctionality Molecular Design & Material Architecture
Erschienen in Crystals
Verlag MDPI
Band 11
Heft 11
Seiten Art.-Nr. 1381
Bemerkung zur Veröffentlichung This article belongs to the Special Issue Relationships between Processing and Properties of Magnesium-Based Alloys
Gefördert durch den KIT-Publikationsfonds
Vorab online veröffentlicht am 12.11.2021
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