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Molecular Probes, Chemosensors, and Nanosensors for Optical Detection of Biorelevant Molecules and Ions in Aqueous Media and Biofluids

Krämer, Joana ORCID iD icon; Kang, Rui; Grimm, Laura M.; De Cola, Luisa; Picchetti, Pierre ORCID iD icon; Biedermann, Frank

Abstract:

Synthetic molecular probes, chemosensors, and nanosensors used in combination with innovative assay protocols hold great potential for the development of robust, low-cost, and fast-responding sensors that are applicable in biofluids (urine, blood, and saliva). Particularly, the development of sensors for metabolites, neurotransmitters, drugs, and inorganic ions is highly desirable due to a lack of suitable biosensors. In addition, the monitoring and analysis of metabolic and signaling networks in cells and organisms by optical probes and chemosensors is becoming increasingly important in molecular biology and medicine. Thus, new perspectives for personalized diagnostics, theranostics, and biochemical/medical research will be unlocked when standing limitations of artificial binders and receptors are overcome. In this review, we survey synthetic sensing systems that have promising (future) application potential for the detection of small molecules, cations, and anions in aqueous media and biofluids. Special attention was given to sensing systems that provide a readily measurable optical signal through dynamic covalent chemistry, supramolecular host–guest interactions, or nanoparticles featuring plasmonic effects. ... mehr


Verlagsausgabe §
DOI: 10.5445/IR/1000142550
Originalveröffentlichung
DOI: 10.1021/acs.chemrev.1c00746
Scopus
Zitationen: 151
Web of Science
Zitationen: 143
Dimensions
Zitationen: 171
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Nanotechnologie (INT)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2022
Sprache Englisch
Identifikator ISSN: 0009-2665, 1520-6890
KITopen-ID: 1000142550
HGF-Programm 43.31.02 (POF IV, LK 01) Devices and Applications
Erschienen in Chemical reviews
Verlag American Chemical Society (ACS)
Band 122
Heft 3
Seiten 3459-3636
Vorab online veröffentlicht am 07.01.2022
Nachgewiesen in Web of Science
Scopus
Dimensions
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