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Shape Tailored Magnetic Nanorings for Intracellular Hyperthermia Cancer Therapy

Dias, Carlos Sato Baraldi; Hanchuk, Talita D. M.; Wender, Heberton; Shigeyosi, Willian T.; Kobarg, Jörg; Rossi, André L.; Tanaka, Marcelo N.; Cardoso, Mateus B.; Garcia, Flávio


This work explores a new class of vortex/magnetite/iron oxide nanoparticles designed for magnetic hyperthermia applications. These nanoparticles, named Vortex Iron oxide Particles (VIPs), are an alternative to the traditional Superparamagnetic Iron Oxide Nanoparticles (SPIONs), since VIPs present superior heating power while fulfilling the main requirements for biomedical applications (low cytotoxicity and nonremanent state). In addition, the present work demonstrates that the synthesized VIPs also promote an internalization and aggregation of the particles inside the cell, resulting in a highly localized hyperthermia in the presence of an alternating magnetic field. Thereby, we demonstrate a new and efficient magnetic hyperthermia strategy in which a small, but well localized, concentration of VIPs can promote an intracellular hyperthermia process.

Verlagsausgabe §
DOI: 10.5445/IR/1000142580
Veröffentlicht am 31.01.2022
DOI: 10.1038/s41598-017-14633-0
Zitationen: 37
Web of Science
Zitationen: 34
Zitationen: 40
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Photonenforschung und Synchrotronstrahlung (IPS)
Publikationstyp Zeitschriftenaufsatz
Publikationsmonat/-jahr 12.2017
Sprache Englisch
Identifikator ISSN: 2045-2322
KITopen-ID: 1000142580
Erschienen in Scientific reports
Verlag Nature Research
Band 7
Seiten Art.-Nr.: 14843
Vorab online veröffentlicht am 01.11.2017
Nachgewiesen in Web of Science
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