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Dark-field computed tomography reaches the human scale

Viermetz, Manuel ; Gustschin, Nikolai; Schmid, Clemens; Haeusele, Jakob; Teuffenbach, Maximilian von; Meyer, Pascal 1; Bergner, Frank; Lasser, Tobias; Proksa, Roland; Koehler, Thomas; Pfeiffer, Franz
1 Institut für Mikrostrukturtechnik (IMT), Karlsruher Institut für Technologie (KIT)


X-ray computed tomography (CT) is one of the most commonly used three-dimensional medical imaging modalities today. It has been refined over several decades, with the most recent innovations including dual-energy and spectral photon-counting technologies. Nevertheless, it has been discovered that wave-optical contrast mechanisms—beyond the presently used X-ray attenuation—offer the potential of complementary information, particularly on otherwise unresolved tissue microstructure. One such approach is dark-field imaging, which has recently been introduced and already demonstrated significantly improved radiological benefit in small-animal models, especially for lung diseases. Until now, however, dark-field CT could not yet be translated to the human scale and has been restricted to benchtop and small-animal systems, with scan durations of several minutes or more. This is mainly because the adaption and upscaling to the mechanical complexity, speed, and size of a human CT scanner so far remained an unsolved challenge. Here, we now report the successful integration of a Talbot–Lau interferometer into a clinical CT gantry and present dark-field CT results of a human-sized anthropomorphic body phantom, reconstructed from a single rotation scan performed in 1 s. ... mehr

Verlagsausgabe §
DOI: 10.5445/IR/1000143065
Veröffentlicht am 15.02.2022
DOI: 10.1073/pnas.2118799119
Zitationen: 28
Web of Science
Zitationen: 23
Zitationen: 33
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Mikrostrukturtechnik (IMT)
Publikationstyp Zeitschriftenaufsatz
Publikationsmonat/-jahr 02.2022
Sprache Englisch
Identifikator ISSN: 0027-8424, 1091-6490
KITopen-ID: 1000143065
HGF-Programm 43.35.01 (POF IV, LK 01) Platform for Correlative, In Situ & Operando Charakterizat.
Erschienen in Proceedings of the National Academy of Sciences of the United States of America
Verlag National Academy of Sciences
Band 119
Heft 8
Seiten e2118799119
Vorab online veröffentlicht am 07.02.2022
Schlagwörter Proposal-Nr. 2016-015-010729, Technologien: DLW, EBL, XRL
Nachgewiesen in Dimensions
Web of Science
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