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Integration of Biofunctional Molecules into 3D-Printed Polymeric Micro-/Nanostructures

Berganza, Eider 1; Apte, Gurunath ORCID iD icon 1; Vasantham, Srivatsan K. 1; Nguyen, Thi-Huong ; Hirtz, Michael ORCID iD icon 1
1 Institut für Nanotechnologie (INT), Karlsruher Institut für Technologie (KIT)


Three-dimensional printing at the micro-/nanoscale represents a new challenge in research and development to achieve direct printing down to nanometre-sized objects. Here, FluidFM, a combination of microfluidics with atomic force microscopy, offers attractive options to fabricate hierarchical polymer structures at different scales. However, little is known about the effect of the substrate on the printed structures and the integration of (bio)functional groups into the polymer inks. In this study, we printed micro-/nanostructures on surfaces with different wetting properties, and integrated molecules with different functional groups (rhodamine as a fluorescent label and biotin as a binding tag for proteins) into the base polymer ink. The substrate wetting properties strongly affected the printing results, in that the lateral feature sizes increased with increasing substrate hydrophilicity. Overall, ink modification only caused minor changes in the stiffness of the printed structures. This shows the generality of the approach, as significant changes in the mechanical properties on chemical functionalization could be confounders in bioapplications. ... mehr

Verlagsausgabe §
DOI: 10.5445/IR/1000144259
Veröffentlicht am 25.03.2022
DOI: 10.3390/polym14071327
Zitationen: 3
Web of Science
Zitationen: 3
Zitationen: 3
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Nanotechnologie (INT)
Karlsruhe Nano Micro Facility (KNMF)
Publikationstyp Zeitschriftenaufsatz
Publikationsdatum 25.03.2022
Sprache Englisch
Identifikator ISSN: 2073-4360
KITopen-ID: 1000144259
HGF-Programm 43.31.02 (POF IV, LK 01) Devices and Applications
Erschienen in Polymers
Verlag MDPI
Band 14
Heft 7
Seiten Article no: 1327
Bemerkung zur Veröffentlichung Gefördert durch den KIT-Publikationsfonds
Schlagwörter Project-ID: 2020-023-028470 (DPN)
Nachgewiesen in Dimensions
Web of Science
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