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Anti-Inflammatory Characteristics of Local Anesthetics: Inhibition of TNF-α Secretion of Lipopolysaccharide-Stimulated Leucocytes in Human Blood Samples

Weinschenk, Stefan ; Weiss, Carsten ORCID iD icon 1; Benrath, Justus; Baehr, Volker von; Strowitzki, Thomas; Feißt, Manuel
1 Institut für Biologische und Chemische Systeme (IBCS), Karlsruher Institut für Technologie (KIT)

Abstract:

Background. Local anesthetics (LAs) have potent anti-inflammatory properties. Inflammatory down-regulation is crucial in diseases with overactive immune reactions, such as acute respiratory distress syndrome (ARDS) and chronic inflammation. We investigated the influence of four LAs, procaine, lidocaine, mepivacaine, and bupivacaine, on the reduction of tumor necrosis factor-alpha (TNF-α) secretion in lipopolysaccharide (LPS)-activated human leucocytes. Methods. Blood samples of 28 individuals were stimulated with LPS. The reduction of TNF-α production by each of the four LAs added (0.5 mg/mL) was measured and correlated with biometric variables. A response was defined as reduction to <85% of initial levels. Results. All four LAs down-regulated the TNF-α secretion in 44–61%: Bupivacaine (44.4%), lidocaine (61.5%), mepivacaine (44.4%), and procaine (50% of the individuals, “responders”). The TNF-α secretion was reduced to 67.4, 68.0, 63.6, and 67.1% of the initial values in responders. The effects in both patients and healthy persons were the same. Interindividual responses to LAs were not correlated with the duration or type of complaints, basal TNF-α serum level, sex, BMI, or age of responders. ... mehr

Zugehörige Institution(en) am KIT Institut für Biologische und Chemische Systeme (IBCS)
Institut für Technik der Informationsverarbeitung (ITIV)
Publikationstyp Zeitschriftenaufsatz
Publikationsdatum 21.03.2022
Sprache Englisch
Identifikator ISSN: 1422-0067
KITopen-ID: 1000144262
HGF-Programm 47.14.02 (POF IV, LK 01) Information Storage and Processing in the Cell Nucleus
Erschienen in International Journal of Molecular Sciences
Verlag MDPI
Band 23
Heft 6
Seiten Article no: 3283
Vorab online veröffentlicht am 18.03.2022
Nachgewiesen in Scopus
Web of Science
Dimensions
OpenAlex
Globale Ziele für nachhaltige Entwicklung Ziel 3 – Gesundheit und Wohlergehen

Verlagsausgabe §
DOI: 10.5445/IR/1000144262
Veröffentlicht am 25.03.2022
Originalveröffentlichung
DOI: 10.3390/ijms23063283
Scopus
Zitationen: 10
Web of Science
Zitationen: 13
Dimensions
Zitationen: 15
Seitenaufrufe: 158
seit 25.03.2022
Downloads: 103
seit 28.03.2022
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