Companies struggle to overcome the difficulties stemming from the dynamic environment of global production due to the specific conditions in different regions. Particularly, insufficient know-how about a regionalized implementation strategy of smart automation (SmAu) technologies is one significant difficulty for enterprises. Thus, developing a key performance indicator (KPI) oriented, regionalized implementation strategy for smart automation technologies is increasingly important. In this context, a new approach is exposed to systematically investigate and identify the interdependencies among location factors, smart automation technologies, and KPIs. Firstly, the environment consisting of location-related factors, KPIs and smart automation technologies is defined in detail. Further, a Catalog quantifies the influence of different regions in China. Secondly, important aspects to model the qualitative and quantitative interdependencies in a multimethod simulation are introduced. Subsequently, an approach to analyze suitable implementation strategies is presented. A case study based on a production line for digitalized production technology is used to validate the proposed approach.