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Passerini chemistries for synthesis of polymer pro-drug and polymersome drug delivery nanoparticles

Travanut, Alessandra; Monteiro, Patrícia F.; Smith, Sean; Howdle, Steven M.; Grabowska, Anna M.; Kellam, Barrie; Meier, Michael A. R. 1,2; Alexander, Cameron
1 Institut für Biologische und Chemische Systeme (IBCS), Karlsruher Institut für Technologie (KIT)
2 Institut für Organische Chemie (IOC), Karlsruher Institut für Technologie (KIT)

Abstract:

New materials chemistries are urgently needed to overcome the limitations of existing biomedical materials in terms of preparation, functionality and versatility, and also in regards to their compatibility with biological environments. Here, we show that Passerini reactions are especially suited for the preparation of drug delivery materials, as with relatively few steps, polymers can be synthesized with functionality installed enabling drug conjugation and encapsulation, self-assembly into micellar or vesicular architectures, and with facile attachment triggerable chemistries. The polymers can be made with a variety of building blocks and assemble into nanoparticles, which are rapidly internalized in triple negative breast cancer (TNBC) cells. In addition, the polymers transport drug molecules efficiently through 3D cell cultures, and when designed with chemistries allowing pH-mediated release, exhibit greater efficacy against TNBC cells compared to the parent drug.


Verlagsausgabe §
DOI: 10.5445/IR/1000146614
Veröffentlicht am 19.05.2022
Originalveröffentlichung
DOI: 10.1039/d2tb00045h
Scopus
Zitationen: 6
Web of Science
Zitationen: 5
Dimensions
Zitationen: 6
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Biologische und Chemische Systeme (IBCS)
Institut für Organische Chemie (IOC)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2022
Sprache Englisch
Identifikator ISSN: 2050-750X, 2050-7518
KITopen-ID: 1000146614
HGF-Programm 43.33.11 (POF IV, LK 01) Adaptive and Bioinstructive Materials Systems
Erschienen in Journal of Materials Chemistry B
Verlag Royal Society of Chemistry (RSC)
Band 10
Heft 20
Seiten 3895-3905
Vorab online veröffentlicht am 19.04.2022
Nachgewiesen in Web of Science
Scopus
Dimensions
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