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C-H Functionalization and C-N Bond Formation Approaches under Catalytic Conditions for the Synthesis of α-Ketoamides and 2,4-Disubstituted-1,3,5-triazines

Singh, Laimujam Sidartha; Kabi, Arup K.; Sengupta, Ragini 1; Roy, Anupam; Sahoo, Abhishek; Saha, Indranil; Malakar, Chandi C.
1 Institut für Photonenforschung und Synchrotronstrahlung (IPS), Karlsruher Institut für Technologie (KIT)

Abstract:

This work describes an easy way to perform approach for the transformation of arylmethyl ketones to α-ketoamides using secondary amines as starting materials in the presence of iodine as a catalyst in water under peroxide free reaction conditions. The established amidation reaction proceeds via α-C(sp3)-H functionalization and C-N bond formation approaches in water at ambient temperature. On the other hand, a novel and straightforward synthesis of 2,4-disubstituted-1,3,5-triazines via nickel-catalyzed cyclization of amidines with DMSO as one-carbon synthon has been developed. The developed strategy proceeds via C-N bond formation.


Verlagsausgabe §
DOI: 10.5445/IR/1000148453
Veröffentlicht am 11.07.2022
Originalveröffentlichung
DOI: 10.14233/ajchem.2022.23769
Scopus
Zitationen: 1
Dimensions
Zitationen: 1
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Photonenforschung und Synchrotronstrahlung (IPS)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2022
Sprache Englisch
Identifikator ISSN: 0970-7077
KITopen-ID: 1000148453
Erschienen in Asian journal of chemistry
Verlag Asian Publication Corporation
Band 34
Heft 7
Seiten 1841–1847
Vorab online veröffentlicht am 15.06.2022
Schlagwörter C-N bond formation, Amidation, Iodine-catalyzed, C1-synthon, 1,3,5-Triazines
Nachgewiesen in Scopus
Dimensions
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