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Dyssynchronous Left Ventricular Activation is Insufficient for the Breakdown of Wringing Rotation

Gerach, Tobias ORCID iD icon 1; Appel, Stephanie 1; Wilczek, Jacek; Golba, Krzysztof S.; Jadczyk, Tomasz; Loewe, Axel ORCID iD icon 1
1 Institut für Biomedizinische Technik (IBT), Karlsruher Institut für Technologie (KIT)

Abstract:

Cardiac resynchronization therapy is a valuable tool to restore left ventricular function in patients experiencing dyssynchronous ventricular activation. However, the non-responder rate is still as high as 40%. Recent studies suggest that left ventricular torsion or specifically the lack thereof might be a good predictor for the response of cardiac resynchronization therapy. Since left ventricular torsion is governed by the muscle fiber orientation and the heterogeneous electromechanical activation of the myocardium, understanding the relation between these components and the ability to measure them is vital. To analyze if locally altered electromechanical activation in heart failure patients affects left ventricular torsion, we conducted a simulation study on 27 personalized left ventricular models. Electroanatomical maps and late gadolinium enhanced magnetic resonance imaging data informed our in-silico model cohort. The angle of rotation was evaluated in every material point of the model and averaged values were used to classify the rotation as clockwise or counterclockwise in each segment and sector of the left ventricle. 88% of the patient models (n = 24) were classified as a wringing rotation and 12% (n = 3) as a rigid-body-type rotation. ... mehr


Verlagsausgabe §
DOI: 10.5445/IR/1000148707
Veröffentlicht am 15.07.2022
Originalveröffentlichung
DOI: 10.3389/fphys.2022.838038
Scopus
Zitationen: 3
Web of Science
Zitationen: 1
Dimensions
Zitationen: 3
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Biomedizinische Technik (IBT)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2022
Sprache Englisch
Identifikator ISSN: 1664-042X
KITopen-ID: 1000148707
Erschienen in Frontiers in Physiology
Verlag Frontiers Media SA
Band 13
Seiten Art.-Nr.: 838038
Bemerkung zur Veröffentlichung Gefördert durch den KIT-Publikationsfonds
Vorab online veröffentlicht am 09.05.2022
Nachgewiesen in Web of Science
Scopus
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