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Origin and Evolution of Enzymes with MIO Prosthetic Group: Microbial Coevolution After the Mass Extinction Event

Peng, Fei 1; Engel, Ulrike; Aliyu, Habibu; Rudat, Jens 1
1 Institut für Bio- und Lebensmitteltechnik (BLT), Karlsruher Institut für Technologie (KIT)


After major mass extinction events, ancient plants and terrestrial vertebrates were faced with various challenges, especially ultraviolet (UV) light. These stresses probably resulted in changes in the biosynthetic pathways, which employed the MIO (3,5-dihydro-5-methylidene-4H-imidazole-4-one)-dependent enzymes (ammonia-lyase and aminomutase), leading to enhanced accumulation of metabolites for defense against UV radiation, pathogens, and microorganisms. Up to now, the origin and evolution of genes from this superfamily have not been extensively studied. In this report, we perform an analysis of the phylogenetic relations between the members of the aromatic amino acid MIO-dependent enzymes (AAM), which demonstrate that they most probably have a common evolutionary origin from ancient bacteria. In early soil environments, numerous bacterial species with tyrosine ammonia-lyase genes (TAL; EC developed tyrosine aminomutase (TAM; EC activity as a side reaction for competing with their neighbors in the community. These genes also evolved into other TAL-like enzymes, such as histidine ammonia-lyase (HAL, EC and phenylalanine ammonia-lyase (PAL; EC, in different bacterial species for metabolite production and accumulation for adaptation to adverse terrestrial environmental conditions. ... mehr

Verlagsausgabe §
DOI: 10.5445/IR/1000149102
Veröffentlicht am 27.07.2022
DOI: 10.3389/fgene.2022.851738
Zitationen: 2
Zitationen: 1
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Bio- und Lebensmitteltechnik (BLT)
Publikationstyp Zeitschriftenaufsatz
Publikationsmonat/-jahr 03.2022
Sprache Englisch
Identifikator ISSN: 1664-8021
KITopen-ID: 1000149102
Erschienen in Frontiers in Genetics
Verlag Frontiers Media SA
Band 13
Seiten Art.-Nr. 851738
Bemerkung zur Veröffentlichung Gefördert durch den KIT-Publikationsfonds
Vorab online veröffentlicht am 29.03.2022
Nachgewiesen in Web of Science
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