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Comparison of Propagation Models and Forward Calculation Methods on Cellular, Tissue and Organ Scale Atrial Electrophysiology

Nagel, Claudia 1; Espinosa, Cristian Barrios 1; Gillette, Karli; Gsell, Matthias A. F.; Sanchez, Jorge 1; Plank, Gernot; DOssel, Olaf 1; Loewe, Axel ORCID iD icon 1
1 Institut für Biomedizinische Technik (IBT), Karlsruher Institut für Technologie (KIT)

Abstract:

The bidomain model and the finite element method are an established standard to mathematically describe cardiac electrophysiology, but are both suboptimal choices for fast and large-scale simulations due to high computational costs. We investigate to what extent simplified approaches for propagation models (monodomain, reaction-Eikonal and Eikonal) and forward calculation (boundary element and infinite volume conductor) deliver markedly accelerated, yet physiologically accurate simulation results in atrial electrophysiology. Methods: We compared action potential durations, local activation times (LATs), and electrocardiograms (ECGs) for sinus rhythm simulations on healthy and fibrotically infiltrated atrial models. Results: All simplified model solutions yielded LATs and P waves in accurate accordance with the bidomain results. Only for the Eikonal model with pre-computed action potential templates shifted in time to derive transmembrane voltages, repolarization behavior notably deviated from the bidomain results. ECGs calculated with the boundary element method were characterized by correlation coefficients >0.9 compared to the finite element method. ... mehr


Verlagsausgabe §
DOI: 10.5445/IR/1000150114
Veröffentlicht am 23.02.2023
Originalveröffentlichung
DOI: 10.1109/TBME.2022.3196144
Scopus
Zitationen: 3
Web of Science
Zitationen: 1
Dimensions
Zitationen: 9
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Biomedizinische Technik (IBT)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2022
Sprache Englisch
Identifikator ISSN: 0018-9294, 1558-2531
KITopen-ID: 1000150114
Erschienen in IEEE Transactions on Biomedical Engineering
Verlag Institute of Electrical and Electronics Engineers (IEEE)
Band 70
Heft 2
Seiten 511 - 522
Nachgewiesen in Scopus
Web of Science
Dimensions
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