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Pt (Ⅱ) complexes-based assays for small biomolecules detection in aqueous media

Kang, Rui 1
1 Institut für Nanotechnologie (INT), Karlsruher Institut für Technologie (KIT)

Abstract (englisch):

Supramolecular principles such as self-assembly, stimuli-responsiveness, and adaptiveness are widely utilized concepts for developing advanced functional materials. Particularly, they have also significantly impacted analytical science development. In the last two decades, countless supramolecular binders, molecular probes, and chemosensors combined with innovative assays have led to a revolution in molecular sensing and medical diagnostics. Nevertheless, most of these molecular sensing systems are still suffering from either low-binding affinity or low-selectivity or decomposition in complex media such as biofluids, which are the main obstacles limiting their further practical applications. Therefore, the development of new molecular sensing systems that can reach practical requirements is still one of the frontiers in supramolecular chemistry. So far, traditional chromatography-based techniques, e.g., HPLC-MS, are often used for molecular sensing, which are reliable but usually time- and cost-intensive, difficult to do parallel analysis, and require trained personnel. Spectroscopic method-based chemosensors and probes may thus become more suitable for practical applications because of cost-effectiveness, ease of handling, and high-throughput screening ability.
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Volltext §
DOI: 10.5445/IR/1000150350
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Nanotechnologie (INT)
Institut für Organische Chemie (IOC)
Publikationstyp Hochschulschrift
Publikationsdatum 26.10.2022
Sprache Englisch
Identifikator KITopen-ID: 1000150350
HGF-Programm 43.31.02 (POF IV, LK 01) Devices and Applications
Verlag Karlsruher Institut für Technologie (KIT)
Umfang VI, 158 S.
Art der Arbeit Dissertation
Fakultät Fakultät für Chemie und Biowissenschaften (CHEM-BIO)
Institut Institut für Nanotechnologie (INT)
Prüfungsdatum 18.07.2022
Schlagwörter Pt(II) complex, biomolecules sensing, photophysics, supramolecular self-assembling
Referent/Betreuer Ulrich, Anne S.
Cola, Luisa De
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