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Supramolecular Optical Chemosensors and Assays for Sensing of Bioactive Analytes in Water and Biofluids

Prabodh, Amrutha ORCID iD icon 1
1 Fakultät für Chemie und Biowissenschaften (CHEM-BIO), Karlsruher Institut für Technologie (KIT)

Abstract (englisch):

The recognition and detection of biologically important analytes, especially small biomolecules, is of prime relevance and has become an upsurging area of research in chemistry and biology. Consequently, the development of robust chemical molecular sensors (“chemosensors”) based on artificial recognition elements with the potential to detect molecules with high sensitivity and selectivity and coupled with a sensitive signal transduction strategy continues to attract considerable attention. Optical methods based on fluorescence are highly desirable for signal transduction because of their versatility, high sensitivity, low cost with readily available instrumentation, and potential for real-time analysis. Thus, optical/fluorescent chemosensors, in combination with innovative assay protocols, find broad application potential in many disciplines, such as biochemistry and clinical and medical diagnostics. They offer a cost efficient alternative to conventional instrumental analytical methods, such as HPLC-MS, GC-MS, and NMR, and are superior to biosensors in terms of stability, equilibration time, price, and scope for small molecule detection. ... mehr


Volltext §
DOI: 10.5445/IR/1000150512
Veröffentlicht am 28.11.2022
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Nanotechnologie (INT)
Institut für Organische Chemie (IOC)
Publikationstyp Hochschulschrift
Publikationsdatum 28.11.2022
Sprache Englisch
Identifikator KITopen-ID: 1000150512
HGF-Programm 43.31.02 (POF IV, LK 01) Devices and Applications
Verlag Karlsruher Institut für Technologie (KIT)
Umfang 215 S.
Art der Arbeit Dissertation
Fakultät Fakultät für Chemie und Biowissenschaften (CHEM-BIO)
Institut Institut für Nanotechnologie (INT)
Prüfungsdatum 20.07.2022
Schlagwörter Supramolecular Chemistry, Optical Chemosensors, Host-Guest Chemistry, Biomolecule and Drug Sensing
Referent/Betreuer Levkin, Pavel
Ulrich, Anne
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