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Refining the Eikonal Model to Reproduce the Influence of Atrial Tissue Geometry on Conduction Velocity

Skupien, Nils 1; Barrios Espinosa, Cristian; Dössel, Olaf 1; Loewe, Axel ORCID iD icon 1
1 Institut für Biomedizinische Technik (IBT), Karlsruher Institut für Technologie (KIT)

Abstract:

Atrial fibrillation is responsible for a significant and steadily rising burden. Simultaneously, the treatment options for atrial fibrillation are far from optimal. Personalized simulations of cardiac electrophysiology could assist clinicians in the risk stratification and therapy planning for atrial fibrillation. However, the use of personalized simulations in clinics is currently not possible due to either too high computational costs or non-sufficient accuracy. Eikonal simulations come with low computational costs but cannot replicate the influence of cardiac tissue geometry on the conduction velocity of the wave propagation. Consequently, they currently lack the required accuracy to be applied in clinics. Biophysically detailed simulations on the other hand are accurate but associated with too high computational costs. To tackle this issue, a regression model is created based on biophysically detailed bidomain simulation data. This regression formula calculates the conduction velocity dependent on the thickness and curvature of the heart wall. Afterwards the formula was implemented into the eikonal model with the goal to increase the accuracy of the eikonal model without losing its advantage of computational efficiency. ... mehr


Verlagsausgabe §
DOI: 10.5445/IR/1000151295
Veröffentlicht am 12.10.2022
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Biomedizinische Technik (IBT)
Publikationstyp Zeitschriftenaufsatz
Publikationsdatum 02.09.2022
Sprache Englisch
Identifikator ISSN: 2364-5504
KITopen-ID: 1000151295
Erschienen in Current Directions in Biomedical Engineering
Verlag De Gruyter
Band 8
Heft 2
Seiten 133–136
Schlagwörter cardiac modelling; eikonal model; conduction velocity; wall thickness; tissue curvature; atrial fibrillation
Nachgewiesen in Dimensions
Scopus
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