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The impact of tumor metabolic activity assessed by $^{18}$F-FET amino acid PET imaging in particle radiotherapy of high-grade glioma patients

Waltenberger, Maria; Furkel, Jennifer; Röhrich, Manuel; Salome, Patrick; Debus, Charlotte 1; Tawk, Bouchra; Gahlawat, Aoife Ward; Kudak, Andreas; Dostal, Matthias; Wirkner, Ute; Schwager, Christian; Herold-Mende, Christel; Combs, Stephanie E.; König, Laila; Debus, Jürgen; Haberkorn, Uwe; Abdollahi, Amir; Knoll, Maximilian
1 Scientific Computing Center (SCC), Karlsruher Institut für Technologie (KIT)

Abstract:

Selective uptake of (18)F-fluoro-ethyl-tyrosine ($^{18}$F-FET) is used in high-grade glioma (HGG) to assess tumor metabolic activity via positron emission tomography (PET). We aim to investigate its value for target volume definition, as a prognosticator, and associations with whole-blood transcriptome liquid biopsy (WBT lbx) for which we recently reported feasibility to mirror tumor characteristics and response to particle irradiation in recurrent HGG (rHGG).


Verlagsausgabe §
DOI: 10.5445/IR/1000151789
Veröffentlicht am 28.10.2022
Originalveröffentlichung
DOI: 10.3389/fonc.2022.901390
Scopus
Web of Science
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Cover der Publikation
Zugehörige Institution(en) am KIT Scientific Computing Center (SCC)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2022
Sprache Englisch
Identifikator ISSN: 2234-943X
KITopen-ID: 1000151789
HGF-Programm 46.21.04 (POF IV, LK 01) HAICU
Erschienen in Frontiers in Oncology
Verlag Frontiers Media SA
Band 12
Seiten Art.Nr. 901390
Vorab online veröffentlicht am 20.09.2022
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