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Reduced Real-life Affective Well-being and Amygdala Habituation in Unmedicated Community Individuals at Risk for Depression and Anxiety

Berhe, Oksana; Höflich, Anna; Moessnang, Carolin; Reichert, Markus 1; Kremer, Thomas; Gan, Gabriela; Ma, Ren; Braun, Urs; Reininghaus, Ulrich; Ebner-Priemer, Ulrich 1; Meyer-Lindenberg, Andreas; Tost, Heike
1 Institut für Sport und Sportwissenschaft (IfSS), Karlsruher Institut für Technologie (KIT)

Abstract:

Background: Early identification of risk for depression and anxiety disorders is important for prevention, but real-life affective well-being and its biological underpinnings in the population remain understudied. Here, we combined methods from epidemiology, psychology, ecological momentary assessment, and functional magnetic resonance imaging to study real-life and neural affective functions in individuals with subclinical anxiety and depression from a population-based cohort of young adults.
Methods: We examined psychological measures, real-life affective valence, functional magnetic resonance imaging amygdala habituation to negative affective stimuli, and the relevance of neural readouts for daily-life affective function in 132 non–help-seeking community individuals. We compared psychological and ecological momentary assessment measures of 61 unmedicated individuals at clinical risk for depression and anxiety (operationalized as subthreshold depression and anxiety symptoms or a former mood or anxiety disorder) with those of 48 nonrisk individuals and 23 persons with a mood or anxiety disorder. We studied risk-associated functional magnetic resonance imaging signals in subsamples with balanced sociodemographic and image quality parameters (26 nonrisk, 26 at-risk persons).
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Zugehörige Institution(en) am KIT Institut für Sport und Sportwissenschaft (IfSS)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2022
Sprache Englisch
Identifikator ISSN: 2451-9022, 2451-9030
KITopen-ID: 1000152344
Erschienen in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
Verlag Elsevier
Band 8
Heft 1
Seiten 111-120
Vorab online veröffentlicht am 24.06.2022
Schlagwörter Anxiety disorders, Community sample, Ecologic momentary assessment, Functional neuroimaging, Major depression, Mental health risk
Nachgewiesen in Dimensions
Web of Science
OpenAlex
Scopus
Globale Ziele für nachhaltige Entwicklung Ziel 3 – Gesundheit und Wohlergehen

Verlagsausgabe §
DOI: 10.5445/IR/1000152344
Veröffentlicht am 07.11.2022
Originalveröffentlichung
DOI: 10.1016/j.bpsc.2022.06.009
Scopus
Zitationen: 1
Dimensions
Zitationen: 3
Seitenaufrufe: 87
seit 07.11.2022
Downloads: 50
seit 07.11.2022
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