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Ferulic acid is a putative surrender signal to stimulate programmed cell death in grapevines after infection with Neofusicoccum parvum

Khattab, Islam M. ORCID iD icon 1; Fischer, Jochen; Kaźmierczak, Andrzej; Thines, Eckhard; Nick, Peter 1
1 Botanisches Institut (BOTANIK), Karlsruher Institut für Technologie (KIT)

Abstract:

An apoplectic breakdown from grapevine trunk diseases (GTDs) has become a serious challenge to viticulture as a consequence of drought stress. We hypothesize that fungal aggressiveness is controlled by a chemical communication between the host and colonizing fungus. We introduce the new concept of a ‘plant surrender signal’ accumulating in host plants under stress and facilitating the aggressive behaviour of the strain Neofusicoccum parvum (Bt-67) causing Botryosphaeriaceae-related dieback in grapevines. Using a cell-based experimental system (Vitis cells) and bioactivity-guided fractionation, we identify trans-ferulic acid, a monolignol precursor, as a ‘surrender signal’. We show that this signal specifically activates the secretion of the fungal phytotoxin fusicoccin A aglycone. We show further that this phytotoxin, mediated by 14-3-3 proteins, activates programmed cell death in Vitis cells. We arrive at a model showing a chemical communication facilitating fusicoccin A secretion that drives necrotrophic behaviour during Botryosphaeriaceae–Vitis interaction through trans-ferulic acid. We thus hypothesize that channelling the phenylpropanoid pathway from this lignin precursor to the trans-resveratrol phytoalexin could be a target for future therapy.


Verlagsausgabe §
DOI: 10.5445/IR/1000152640
Veröffentlicht am 14.11.2022
Originalveröffentlichung
DOI: 10.1111/pce.14468
Scopus
Zitationen: 8
Web of Science
Zitationen: 7
Dimensions
Zitationen: 8
Cover der Publikation
Zugehörige Institution(en) am KIT Botanisches Institut (BOTANIK)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2022
Sprache Englisch
Identifikator ISSN: 0140-7791, 1365-3040
KITopen-ID: 1000152640
Erschienen in Plant, Cell & Environment
Verlag John Wiley and Sons
Band 46
Heft 1
Seiten 339-358
Vorab online veröffentlicht am 20.10.2022
Schlagwörter Apoplexy, Botryosphaeriaceae-related dieback, fusicoccin A, plant surrender signal
Nachgewiesen in Dimensions
Web of Science
Scopus
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