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Longitudinal association between physical activity and the risk of incident metabolic syndrome in middle-aged adults in Germany

Cleven, Laura ORCID iD icon 1; Krell-Rösch, Janina ORCID iD icon 1; Schmidt, Steffen 1; Dziuba, Anna 1; Bös, Klaus 1; Jekauc, Darko 1; Woll, Alexander ORCID iD icon 1
1 Institut für Sport und Sportwissenschaft (IfSS), Karlsruher Institut für Technologie (KIT)


We examined the longitudinal association between physical activity (PA) and the risk of incident metabolic syndrome (MetS) among middle-aged, community-dwelling adults, including 591 individuals (314 females; mean (SD) age, 43.8 (8.5) years) who were free of MetS at baseline. Habitual and sports-related PA was assessed by a self-reported questionnaire. MetS was defined based on HDL-cholesterols, triglycerides, glucose or HbA1c, blood pressure, and waist circumference. We calculated Cox proportional hazard ratios (HR) and 95% confidence intervals (CI) using regression analyses. Over a mean follow-up of 12.5 years, 205 participants developed incident MetS. Four different sports-related PA measures were associated with a decreased risk of incident MetS: (1) Engaging in ≥ 75 min/week (HR 0.71, 95% CI 0.53–0.94), (2) maintaining a continuously high amount from baseline to follow-up of ≥ 75 min/week (HR 0.66, 95% CI 0.46–0.94), (3) starting from < 150 min/week at baseline to ≥ 150 min/week at follow-up (HR 0.65, 95% CI 0.45–0.94), and (4) increasing from < 16.6 MET-hours/week at baseline to ≥ 16.6 MET-hours/week at follow-up (HR 0.47, 95% CI 0.31–0.71). ... mehr

Verlagsausgabe §
DOI: 10.5445/IR/1000152641
Veröffentlicht am 15.11.2022
DOI: 10.1038/s41598-022-24052-5
Zitationen: 5
Zitationen: 4
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Sport und Sportwissenschaft (IfSS)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2022
Sprache Englisch
Identifikator ISSN: 0068-1261
KITopen-ID: 1000152641
Erschienen in Scientific reports
Verlag Nature Research
Band 12
Heft 1
Seiten Art.-Nr.: 19424
Bemerkung zur Veröffentlichung Gefördert durch den KIT-Publikationsfonds
Vorab online veröffentlicht am 12.11.2022
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