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Diffusion Reaction Eikonal Alternant Model: Towards Fast Simulations of Complex Cardiac Arrhythmias

Barrios Espinosa, Cristian A. 1; Sánchez, Jorge 1; Doessel, Olaf 1; Loewe, Axel ORCID iD icon 1
1 Institut für Biomedizinische Technik (IBT), Karlsruher Institut für Technologie (KIT)

Abstract:

Reaction-diffusion (RD) computer models are suitable to investigate the mechanisms of cardiac arrthymias but not directly applicable in clinical settings due to their computational cost. On the other hand, alternative faster eikonal models are incapable of reproducing reentrant activation when solved by iterative methods. The diffusion reaction eikonal alternant model (DREAM) is a new method in which eikonal and RD models are alternated to allow for reactivation. To solve the eikonal equation, the fast iterative method was modified and embedded into DREAM. Obtained activation times control transmembrane voltage courses in the RD model computing, while repolarization times are provided back to the eikonal model. For a planar wave-front in the center of a 2D patch, DREAM action potentials (APs) have a small overshoot in the upstroke compared to pure RD simulations (monodomain) but similar AP duration. DREAM conduction velocity does not increase near boundaries or stimulated areas as it occurs in RD. Anatomical reentry was reproduced with the S1-S2 protocol. This is the first time that an iterative method is used to solve the eikonal model in a version that admits reactivation. ... mehr


Verlagsausgabe §
DOI: 10.5445/IR/1000158437
Veröffentlicht am 05.05.2023
Originalveröffentlichung
DOI: 10.22489/CinC.2022.054
Scopus
Zitationen: 2
Dimensions
Zitationen: 3
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Biomedizinische Technik (IBT)
Publikationstyp Proceedingsbeitrag
Publikationsjahr 2022
Sprache Englisch
Identifikator ISBN: 979-83-503-0097-0
ISSN: 2325-887X
KITopen-ID: 1000158437
Erschienen in 2022 Computing in Cardiology Conference (CinC)
Veranstaltung 49th Computing in Cardiology (CinC 2022), Tampere, Finnland, 04.09.2022 – 07.09.2022
Verlag Institute of Electrical and Electronics Engineers (IEEE)
Serie Computing in Cardiology Conference (CinC)
Nachgewiesen in Dimensions
Scopus
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