KIT | KIT-Bibliothek | Impressum | Datenschutz

Effects of Ventricular Myofiber Orientation on Mechanical Function in Human Heart Simulations

Krauß, Jonathan 1; Gerach, Tobias ORCID iD icon 1; Loewe, Axel ORCID iD icon 1
1 Institut für Biomedizinische Technik (IBT), Karlsruher Institut für Technologie (KIT)

Abstract:

Currently, personalization of computational human heart models is often performed by combining a carefully designed patient-specific heart geometry with a generic myofiber orientation. This is due to a lack of accurate in vivo fiber orientation measurement techniques. In this study, we use a mechanical whole-heart model to evaluate the impact of ventricular fiber angles and sheet angles on clinically relevant mechanical biomarkers of the left ventricle (LV): wall thickening W T , mitral valve displacement M V D, net LV twist angle θ and ejection fraction EF . We show that the mechanical function is strongly dependent on the fiber direction. In the evaluated fiber angle configurations, W T ranged from 33.38 % to 52.48 %, M V D from 5.85 mm to 18.19 mm and EF from 46.83 % to 59.95 %. For some fiber angles, θ was negative. Additionally, θ was the only biomarker undergoing significant changes for different sheet angles. For W T , M V D and EF the impact of sheet angle combinations was negligible (< 4.6 %), unless changes in the active stress tensor were introduced. Even then, the change between different sheet angle combinations is small compared to the change between different stress tensor formulations. ... mehr


Zugehörige Institution(en) am KIT Institut für Biomedizinische Technik (IBT)
Publikationstyp Proceedingsbeitrag
Publikationsjahr 2022
Sprache Englisch
Identifikator ISBN: 979-83-503-0097-0
ISSN: 2325-887X
KITopen-ID: 1000158445
Erschienen in 2022 Computing in Cardiology Conference (CinC)
Veranstaltung 49th Computing in Cardiology (CinC 2022), Tampere, Finnland, 04.09.2022 – 07.09.2022
Verlag Institute of Electrical and Electronics Engineers (IEEE)
Serie 2022 Computing in Cardiology Conference (CinC)
Nachgewiesen in Scopus
Dimensions
KIT – Die Forschungsuniversität in der Helmholtz-Gemeinschaft
KITopen Landing Page