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Amikacin@SiO$_{2}$ core@shell nanocarriers to treat pulmonal bacterial infections

Rutschmann, Mark 1; Redinger, N.; Redinger, Natalja; Schaible, Ulrich E.
1 Institut für Anorganische Chemie (AOC), Karlsruher Institut für Technologie (KIT)

Abstract:

AMC@SiO$_{2}$ core@shell nanocarriers (AMC: amikacin) are realized and contain an exceptionally high drug load of 0.8 mg mg$^{-1}$ (i.e. 80% AMC of total nanocarrier mass). They are prepared via a solvent–antisolvent approach with AMC nanoparticles formed in a first step, which are then covered and stabilised by a thin silica shell in a one-pot synthesis. In total, the core@shell nanocarriers exhibit a mean diameter of 240 nm with an inner AMC core of 200 nm and an outer silica shell of 20 nm. Subsequent to synthesis, the nanocarriers can be stored in frozen dimethylsulfoxide (DMSO) and applied directly after warming to room temperature with particle contents of 5 mg mL$^{-1}$. Size, structure, and composition of the AMC@SiO$_{2}$ core@shell nanocarriers are evidenced by electron microscopy (SEM, TEM), spectroscopic methods (EDXS, FT-IR, UV-Vis), as well as X-ray powder diffraction and elemental analysis. As proof-of-concept, the AMC release and the activity of the novel nanocarriers are tested against two relevant, difficult-to-treat and notoriously multidrug resistant, bacterial pathogens: Mycobacterium tuberculosis (M.tb.) and Mycobacterium abscessus (M.abs.). ... mehr


Verlagsausgabe §
DOI: 10.5445/IR/1000159121
Veröffentlicht am 05.07.2023
Originalveröffentlichung
DOI: 10.1039/D2TB02609K
Scopus
Zitationen: 2
Web of Science
Zitationen: 2
Dimensions
Zitationen: 3
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Anorganische Chemie (AOC)
Publikationstyp Zeitschriftenaufsatz
Publikationsdatum 21.06.2023
Sprache Englisch
Identifikator ISSN: 2050-750X, 2050-7518
KITopen-ID: 1000159121
Erschienen in Journal of Materials Chemistry B
Verlag Royal Society of Chemistry (RSC)
Band 11
Heft 24
Seiten 5460–5468
Nachgewiesen in Scopus
Dimensions
Web of Science
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