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Microbial Metabolism of the Soy Isoflavones Daidzein and Genistein in Postmenopausal Women: Human Intervention Study Reveals New Metabotypes

Soukup, Sebastian T.; Engelbert, Ann Katrin; Watzl, Bernhard; Bub, Achim; Kulling, Sabine E.

Abstract:

Background: Soy isoflavones belong to the group of phytoestrogens and are associated with beneficial health effects but are also discussed to have adverse effects. Isoflavones are intensively metabolized by the gut microbiota leading to metabolites with altered estrogenic potency. The population is classified into different isoflavone metabotypes based on individual metabolite profiles. So far, this classification was based on the capacity to metabolize daidzein and did not reflect genistein metabolism. We investigated the microbial metabolite profile of isoflavones considering daidzein and genistein. Methods: Isoflavones and metabolites were quantified in the urine of postmenopausal women receiving a soy isoflavone extract for 12 weeks. Based on these data, women were clustered in different isoflavone metabotypes. Further, the estrogenic potency of these metabotypes was estimated. Results: Based on the excreted urinary amounts of isoflavones and metabolites, the metabolite profiles could be calculated, resulting in 5 metabotypes applying a hierarchical cluster analysis. The metabotypes differed in part strongly regarding their metabolite profile and their estimated estrogenic potency.


Verlagsausgabe §
DOI: 10.5445/IR/1000159855
Veröffentlicht am 27.06.2023
Originalveröffentlichung
DOI: 10.3390/nu15102352
Scopus
Zitationen: 11
Web of Science
Zitationen: 9
Dimensions
Zitationen: 10
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Sport und Sportwissenschaft (IfSS)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2023
Sprache Englisch
Identifikator ISSN: 2072-6643
KITopen-ID: 1000159855
Erschienen in Nutrients
Verlag MDPI
Band 15
Heft 10
Schlagwörter isoflavone; daidzein; genistein; human; metabolism; metabotypes
Nachgewiesen in Dimensions
Web of Science
Scopus
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