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Taxane-Induced Neuropathy and Its Ocular Effects—A Longitudinal Follow-up Study in Breast Cancer Patients

Stache, Nadine; Bohn, Sebastian; Sperlich, Karsten; George, Christian; Winter, Karsten; Schaub, Friederike; Do, Ha-Vy; Röhlig, Martin; Reichert, Klaus-Martin 1; Allgeier, Stephan ORCID iD icon 1; Stachs, Oliver; Stachs, Angrit; Sterenczak, Katharina A.
1 Institut für Automation und angewandte Informatik (IAI), Karlsruher Institut für Technologie (KIT)


A common severe neurotoxic side effect of breast cancer (BC) therapy is chemotherapy-induced peripheral neuropathy (CIPN) and intervention is highly needed for the detection, prevention, and treatment of CIPN at an early stage. As the eye is susceptible to neurotoxic stimuli, the present study aims to determine whether CIPN signs in paclitaxel-treated BC patients correlate with ocular changes by applying advanced non-invasive biophotonic in vivo imaging. Patients (n = 14, 10 controls) underwent monitoring sessions after diagnosis, during, and after therapy (T0-T3). Monitoring sessions included general anamnesis, assessment of their quality of life, neurological scores, ophthalmological status, macular optical coherence tomography (OCT), and imaging of their subbasal nerve plexus (SNP) by large-area confocal laser-scanning microscopy (CLSM). At T0, no significant differences were detected between patients and controls. During treatment, patients’ scores significantly changed while the greatest differences were found between T0 and T3. None of the patients developed severe CIPN but retinal thickenings could be detected. CLSM revealed large SNP mosaics with identical areas while corneal nerves remained stable. ... mehr

Verlagsausgabe §
DOI: 10.5445/IR/1000160226
Veröffentlicht am 06.07.2023
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Automation und angewandte Informatik (IAI)
Publikationstyp Zeitschriftenaufsatz
Publikationsmonat/-jahr 05.2023
Sprache Englisch
Identifikator ISSN: 2072-6694
KITopen-ID: 1000160226
HGF-Programm 47.14.02 (POF IV, LK 01) Information Storage and Processing in the Cell Nucleus
Erschienen in Cancers
Verlag MDPI
Band 15
Heft 9
Seiten Art.-Nr.: 2444
Projektinformation CSS-CCM (DFG, DFG EIN, AL 2667/1-1)
Vorab online veröffentlicht am 25.04.2023
Schlagwörter breast cancer therapy, taxanes, neurotoxic events, polyneuropathy, retinal layers, corneal nerves
Nachgewiesen in Scopus
Web of Science
Globale Ziele für nachhaltige Entwicklung Ziel 3 – Gesundheit und Wohlergehen
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