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Spatial correlation of left atrial low voltage substrate in sinus rhythm versus atrial fibrillation: The rhythm specificity of atrial low voltage substrate

Nairn, Deborah ORCID iD icon 1; Eichenlaub, Martin; Lehrmann, Heiko; Müller-Edenborn, Björn; Chen, Juan; Huang, Taiyuan; Nagel, Claudia 1; Sánchez, Jorge 1; Luongo, Giorgio 1; Westermann, Dirk; Arentz, Thomas; Dössel, Olaf 1; Jadidi, Amir; Loewe, Axel ORCID iD icon 1
1 Institut für Biomedizinische Technik (IBT), Karlsruher Institut für Technologie (KIT)

Abstract:

Introduction
Improved sinus rhythm (SR) maintenance rates have been achieved in patients with persistent atrial fibrillation (AF) undergoing pulmonary vein isolation plus additional ablation of low voltage substrate (LVS) during SR. However, voltage mapping during SR may be hindered in persistent and long-persistent AF patients by immediate AF recurrence after electrical cardioversion. We assess correlations between LVS extent and location during SR and AF, aiming to identify regional voltage thresholds for rhythm-independent delineation/detection of LVS areas. (1) Identification of voltage dissimilarities between mapping in SR and AF. (2) Identification of regional voltage thresholds that improve cross-rhythm substrate detection. (3) Comparison of LVS between SR and native versus induced AF.
Methods
Forty-one ablation-naive persistent AF patients underwent high-definition (1 mm electrodes; >1200 left atrial (LA) mapping sites per rhythm) voltage mapping in SR and AF. Global and regional voltage thresholds in AF were identified which best match LVS < 0.5 mV and <1.0 mV in SR. Additionally, the correlation between SR-LVS with induced versus native AF-LVS was assessed.
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Verlagsausgabe §
DOI: 10.5445/IR/1000160568
Veröffentlicht am 21.12.2023
Originalveröffentlichung
DOI: 10.1111/jce.15984
Scopus
Zitationen: 1
Web of Science
Zitationen: 1
Dimensions
Zitationen: 3
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Biomedizinische Technik (IBT)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2023
Sprache Englisch
Identifikator ISSN: 1045-3873, 0736-6108, 0892-1059, 1540-8167, 2374-8338, 2374-8419, 2374-8427, 8756-9264
KITopen-ID: 1000160568
Erschienen in Journal of Cardiovascular Electrophysiology
Verlag John Wiley and Sons
Band 34
Heft 8
Seiten 1613-1621
Vorab online veröffentlicht am 27.06.2023
Schlagwörter atrial fibrillation, induced AF, low voltage substrate, regional analysis, sinus rhythm
Nachgewiesen in Web of Science
Dimensions
Scopus
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