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Insights into the mechanisms of neuron generation and specification in the zebrafish ventral spinal cord

Cucun, Gokhan 1,2; Köhler, Melina 1,2; Pfitsch, Sabrina 1,2; Rastegar, Sepand ORCID iD icon 1,2
1 Institut für Biologische und Chemische Systeme (IBCS), Karlsruher Institut für Technologie (KIT)
2 Zukunftscampus (CAMPUS), Karlsruher Institut für Technologie (KIT)

Abstract:

The vertebrate nervous system is composed of a wide range of neurons and complex synaptic connections, raising the intriguing question of how neuronal diversity is generated. The spinal cord provides an excellent model for exploring the mechanisms governing neuronal diversity due to its simple neural network and the conserved molecular processes involved in neuron formation and specification during evolution. This review specifically examines two distinct progenitor domains present in the zebrafish ventral spinal cord: the lateral floor plate (LFP) and the p2 progenitor domain. The LFP is responsible for the production of GABAergic Kolmer-Agduhr neurons (KA"), glutamatergic V3 neurons and intraspinal serotonergic neurons (ISNs), while the p2 domain generates V2 precursors that subsequently differentiate into three unique subpopulations of V2 neurons, namely glutamatergic V2a, GABAergic V2b and glycinergic V2s. Based on recent findings, we will examine the fundamental signalling pathways and transcription factors that play a key role in the specification of these diverse neurons and neuronal subtypes derived from the LFP and p2 progenitor domains.


Verlagsausgabe §
DOI: 10.5445/IR/1000161047
Veröffentlicht am 04.08.2023
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Biologische und Chemische Systeme (IBCS)
Zukunftscampus (CAMPUS)
Publikationstyp Zeitschriftenaufsatz
Publikationsdatum 27.07.2024
Sprache Englisch
Identifikator ISSN: 1742-464X, 1742-4658
KITopen-ID: 1000161047
HGF-Programm 47.14.02 (POF IV, LK 01) Information Storage and Processing in the Cell Nucleus
Erschienen in The FEBS Journal
Verlag John Wiley and Sons
Band 291
Heft 4
Seiten 646-662
Vorab online veröffentlicht am 26.07.2023
Nachgewiesen in Scopus
Web of Science
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