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Biphasic NMR of Hyperpolarized Suspensions─Real-Time Monitoring of Solute-to-Solid Conversion to Watch Materials Grow

Turhan, Ertan; Pötzl, Christopher; Keil, Waldemar; Negroni, Mattia; Kouřil, Karel 1; Meier, Benno ORCID iD icon 1,2; Romero, Javier Agustin; Kazimierczuk, Krzysztof; Goldberga, Ieva; Azaïs, Thierry; Kurzbach, Dennis
1 Institut für Biologische Grenzflächen (IBG), Karlsruher Institut für Technologie (KIT)
2 Institut für Physikalische Chemie (IPC), Karlsruher Institut für Technologie (KIT)

Abstract:

Nuclear magnetic resonance (NMR) spectroscopy is a key method for the determination of molecular structures. Due to its intrinsically high (i.e., atomistic) resolution and versatility, it has found numerous applications for investigating gases, liquids, and solids. However, liquid-state NMR has found little application for suspensions of solid particles as the resonances of such systems are excessively broadened, typically beyond the detection threshold. Herein, we propose a route to overcoming this critical limitation by enhancing the signals of particle suspensions by >3.000-fold using dissolution dynamic nuclear polarization (d-DNP) coupled with rapid solid precipitation. For the proof-of-concept series of experiments, we employed calcium phosphate (CaP) as a model system. By d-DNP, we boosted the signals of phosphate $^{31}$P spins before rapid CaP precipitation inside the NMR spectrometer, leading to the inclusion of the hyperpolarized phosphate into CaP-nucleated solid particles within milliseconds. With our approach, within only 1 s of acquisition time, we obtained spectra of biphasic systems, i.e., micrometer-sized dilute solid CaP particles coexisting with their solution-state precursors. ... mehr


Verlagsausgabe §
DOI: 10.5445/IR/1000163138
Veröffentlicht am 17.10.2023
Originalveröffentlichung
DOI: 10.1021/acs.jpcc.3c04198
Scopus
Zitationen: 4
Web of Science
Zitationen: 4
Dimensions
Zitationen: 4
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Biologische Grenzflächen (IBG)
Institut für Physikalische Chemie (IPC)
Publikationstyp Zeitschriftenaufsatz
Publikationsdatum 05.10.2023
Sprache Englisch
Identifikator ISSN: 1932-7447, 1932-7455
KITopen-ID: 1000163138
HGF-Programm 43.35.01 (POF IV, LK 01) Platform for Correlative, In Situ & Operando Charakterizat.
Erschienen in The Journal of Physical Chemistry C
Verlag American Chemical Society (ACS)
Band 127
Heft 39
Seiten 19591–19598
Vorab online veröffentlicht am 21.09.2023
Schlagwörter Ions, Nuclear magnetic resonance spectroscopy, Phosphates, Polarization, Solution chemistry
Nachgewiesen in Dimensions
Web of Science
Scopus
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