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Responsive Nucleic Acid-Based Organosilica Nanoparticles

Picchetti, Pierre ORCID iD icon 1; Volpi, Stefano; Rossetti, Marianna; Dore, Michael D.; Trinh, Tuan; Biedermann, Frank 1; Neri, Martina; Bertucci, Alessandro; Porchetta, Alessandro; Corradini, Roberto; Sleiman, Hanadi; De Cola, Luisa 1
1 Institut für Nanotechnologie (INT), Karlsruher Institut für Technologie (KIT)

Abstract:

The development of smart nanoparticles (NPs) that encode responsive features in the structural framework promises to extend the applications of NP-based drugs, vaccines, and diagnostic tools. New nanocarriers would ideally consist of a minimal number of biocompatible components and exhibit multiresponsive behavior to specific biomolecules, but progress is limited by the difficulty of synthesizing suitable building blocks. Through a nature-inspired approach that combines the programmability of nucleic acid interactions and sol–gel chemistry, we report the incorporation of synthetic nucleic acids and analogs, as constitutive components, into organosilica NPs. We prepared different nanomaterials containing single-stranded nucleic acids that are covalently embedded in the silica network. Through the incorporation of functional nucleic acids into the organosilica framework, the particles respond to various biological, physical, and chemical inputs, resulting in detectable physicochemical changes. The one-step bottom-up approach used to prepare organosilica NPs provides multifunctional systems that combine the tunability of oligonucleotides with the stiffness, low cost, and biocompatibility of silica for different applications ranging from drug delivery to sensing.


Verlagsausgabe §
DOI: 10.5445/IR/1000163142
Veröffentlicht am 17.10.2023
Originalveröffentlichung
DOI: 10.1021/jacs.3c00393
Scopus
Zitationen: 6
Web of Science
Zitationen: 6
Dimensions
Zitationen: 6
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Nanotechnologie (INT)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2023
Sprache Englisch
Identifikator ISSN: 0002-7863, 1520-5126
KITopen-ID: 1000163142
HGF-Programm 43.31.02 (POF IV, LK 01) Devices and Applications
Erschienen in Journal of the American Chemical Society
Verlag American Chemical Society (ACS)
Band 145
Heft 42
Seiten 22896–22902
Vorab online veröffentlicht am 21.09.2023
Schlagwörter Biopolymers, Genetics, Hybrid materials, Nanoparticles, Silica
Nachgewiesen in Dimensions
Web of Science
Scopus
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