KIT | KIT-Bibliothek | Impressum | Datenschutz

Biosynthesis of ternary NiCoFe$_2$O$_4$ nanoflowers: investigating their 3D structure and potential use in gene delivery

Alijani, Hajar Q.; Khatami, Mehrdad; Torkzadeh-Mahani, Masoud; Michalička, Jan; Wang, Wu 1; Wang, Di ORCID iD icon 1,2; Heydari, Abolfazl
1 Institut für Nanotechnologie (INT), Karlsruher Institut für Technologie (KIT)
2 Karlsruhe Nano Micro Facility (KNMF), Karlsruher Institut für Technologie (KIT)

Abstract:

Multicomponent nanoparticle systems are known for their varied properties and functions, and have shown potential as gene nanocarriers. This study aims to synthesize and characterize ternary nickel–cobalt-ferrite (NiCoFe$_2$O$_4$) nanoparticles with the potential to serve as gene nanocarriers for cancer/gene therapy. The biogenic nanocarriers were prepared using a simple and eco-friendly method following green chemistry principles. The physicochemical properties of the nanoparticles were analyzed by X-ray diffraction, vibrating sample magnetometer, X-ray photoelectron spectroscopy, and Brunauer–Emmett–Teller. To evaluate the morphology of the nanoparticles, the field emission scanning electron microscopy with energy dispersive X-Ray spectroscopy, high-resolution transmission electron microscopy imaging, and electron tomography were conducted. Results indicate the nanoparticles have a nanoflower morphology with a mesoporous nature and a cubic spinel structure, where the rod and spherical nanoparticles became rose-like with a specific orientation. These nanoparticles were found to have minimal toxicity in human embryonic kidney 293 (HEK-293 T) cells at concentrations of 1 to 250 µg·mL–1. ... mehr


Verlagsausgabe §
DOI: 10.5445/IR/1000163742
Veröffentlicht am 02.11.2023
Originalveröffentlichung
DOI: 10.1186/s13036-023-00381-5
Scopus
Zitationen: 4
Web of Science
Zitationen: 4
Dimensions
Zitationen: 4
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Nanotechnologie (INT)
Karlsruhe Nano Micro Facility (KNMF)
Publikationstyp Zeitschriftenaufsatz
Publikationsmonat/-jahr 12.2023
Sprache Englisch
Identifikator ISSN: 1754-1611
KITopen-ID: 1000163742
HGF-Programm 43.35.01 (POF IV, LK 01) Platform for Correlative, In Situ & Operando Charakterizat.
Erschienen in Journal of Biological Engineering
Verlag Springer Fachmedien Wiesbaden
Band 17
Heft 1
Seiten Art.-Nr.: 61
Vorab online veröffentlicht am 02.10.2023
Schlagwörter Ternary metal nanoflowers, Green Chemistry, 3D electron tomography, Mesoporous biogenic nanocarriers, Gene delivery
Nachgewiesen in Scopus
Dimensions
Web of Science
Globale Ziele für nachhaltige Entwicklung Ziel 3 – Gesundheit und Wohlergehen
KIT – Die Forschungsuniversität in der Helmholtz-Gemeinschaft
KITopen Landing Page