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Electrospun composite nanofibers of deoxyribonucleic acid and polylactic acid for skincare applications

Ullah, Sana; Ali, Hina Ghulam; Hashmi, Motahira; Haider, Md Kaiser; Ishaq, Tehmeena; Tamada, Yasushi; Park, Soyoung ; Kim, Ick Soo

Abstract:

The development of useful biomaterials has resulted in significant advances in various fields of science and technology. The demand for new biomaterial designs and manufacturing techniques continues to grow, with the goal of building a sustainable society. In this study, two types of DNA-cationic surfactant complexes were synthesized using commercially available deoxyribonucleic acid from herring sperm DNA (hsDNA, <50 bp) and deoxyribonucleic acid from salmon testes DNA (stDNA, ~2000 bp). The DNA-surfactant complexes were blended with a polylactic acid (PLA) biopolymer and electrospun to obtain nanofibers, and then copper nanoparticles were synthesized on nanofibrous webs. Scanning electron microscopic images showed that all nanofibers possessed uniform morphology. Interestingly, different diameters were observed depending on the base pairs in the DNA complex. Transmission electron microscopy showed uniform growth of copper nanoparticles on the nanofibers. Fourier-transform infrared spectroscopy spectra confirmed the uniform blending of both types of DNA complexes in PLA. Both stDNA- and hsDNA-derived nanofibers showed greater biocompatibility than native PLA nanofibers. ... mehr


Verlagsausgabe §
DOI: 10.5445/IR/1000168069
Veröffentlicht am 06.02.2024
Originalveröffentlichung
DOI: 10.1002/jbm.a.37592
Scopus
Zitationen: 1
Dimensions
Zitationen: 1
Cover der Publikation
Zugehörige Institution(en) am KIT Helmholtz-Institut Ulm (HIU)
Publikationstyp Zeitschriftenaufsatz
Publikationsmonat/-jahr 11.2023
Sprache Englisch
Identifikator ISSN: 1549-3296, 1552-4965
KITopen-ID: 1000168069
HGF-Programm 38.02.01 (POF IV, LK 01) Fundamentals and Materials
Erschienen in Journal of Biomedical Materials Research Part A
Verlag John Wiley and Sons
Band 111
Heft 11
Seiten 1798–1807
Vorab online veröffentlicht am 04.08.2023
Nachgewiesen in Web of Science
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Scopus
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