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Role of melanocortin system in the locomotor activity rhythms and melatonin secretion as revealed by agouti‐signalling protein ( asip1 ) overexpression in zebrafish

Godino-Gimeno, Alejandra; Leal, Esther; Chivite, Mauro; Tormos, Elisabeth; Rotllant, Josep; Vallone, Daniela 1; Foulkes, Nicholas S. 1; Míguez, Jesús M.; Cerdá-Reverter, Jose Miguel
1 Institut für Biologische und Chemische Systeme (IBCS), Karlsruher Institut für Technologie (KIT)

Abstract:

Temporal signals such as light and temperature cycles profoundly modulate animal physiology and behaviour. Via endogenous timing mechanisms which are regulated by these signals, organisms can anticipate cyclic environmental changes and thereby enhance their fitness. The pineal gland in fish, through the secretion of melatonin, appears to play a critical role in the circadian system, most likely acting as an element of the circadian clock system. An important output of this circadian clock is the locomotor activity circadian rhythm which is adapted to the photoperiod and thus determines whether animals are diurnal or nocturnal. By using a genetically modified zebrafish strain known as Tg (Xla.Eef1a1:Cau.asip1)iim04, which expresses a higher level of the agouti signalling protein 1 (Asip1), an endogenous antagonist of the melanocortin system, we observed a complete disruption of locomotor activity patterns, which correlates with the ablation of the melatonin daily rhythm. Consistent with this, in vitro experiments also demonstrated that Asip1 inhibits melatonin secretion from the zebrafish pineal gland, most likely through the melanocortin receptors expressed in this gland. ... mehr


Verlagsausgabe §
DOI: 10.5445/IR/1000168146
Veröffentlicht am 06.02.2024
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Biologische und Chemische Systeme (IBCS)
Publikationstyp Zeitschriftenaufsatz
Publikationsmonat/-jahr 01.2024
Sprache Englisch
Identifikator ISSN: 0742-3098, 1600-079X
KITopen-ID: 1000168146
HGF-Programm 47.14.02 (POF IV, LK 01) Information Storage and Processing in the Cell Nucleus
Erschienen in Journal of Pineal Research
Verlag John Wiley and Sons
Band 76
Heft 1
Seiten Art.-Nr.: e12939
Vorab online veröffentlicht am 19.01.2024
Schlagwörter agouti, circadian clock, food intake, melanocyte-stimulating hormone (Msh), pineal, pomc, sleep
Nachgewiesen in Dimensions
Web of Science
Scopus
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