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Electrochemically enabled oxidative aromatization of pyrazolines

Hofmann, Silja; Linden, Martin; Neuner, Julian; Weber, Felix N.; Waldvogel, Siegfried R.

Abstract:

Pyrazoles are a very important structural motif widely found in pharmaceuticals and agrochemicals. An electrochemically enabled approach for the sustainable synthesis of pyrazoles via oxidative aromatization of pyrazolines is presented. Inexpensive sodium chloride is employed in a dual role as a redox mediator and supporting electrolyte in a biphasic system (aqueous/organic). The method is applicable to a broad scope and can be conducted in the simplest electrolysis set-up using carbon-based electrodes. Hence, the method allows for simple work-up strategies such as extraction and crystallization, which enables application of this green synthetic route on a technically relevant scale. This is underlined by demonstration of a multi-gram scale electrolysis without loss in yield.


Verlagsausgabe §
DOI: 10.5445/IR/1000168453
Veröffentlicht am 15.02.2024
Originalveröffentlichung
DOI: 10.1039/D3OB00671A
Scopus
Zitationen: 7
Web of Science
Zitationen: 4
Dimensions
Zitationen: 8
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Biologische und Chemische Systeme (IBCS)
Publikationstyp Zeitschriftenaufsatz
Publikationsdatum 07.06.2023
Sprache Englisch
Identifikator ISSN: 1477-0520, 1477-0539
KITopen-ID: 1000168453
HGF-Programm 43.33.11 (POF IV, LK 01) Adaptive and Bioinstructive Materials Systems
Erschienen in Organic & Biomolecular Chemistry
Verlag Royal Society of Chemistry (RSC)
Band 21
Heft 22
Seiten 4694–4701
Nachgewiesen in Dimensions
Web of Science
Scopus
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