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Block Polyelectrolyte Additives That Modulate the Viscoelasticity and Enhance the Printability of Gelatin Inks at Physiological Temperatures

Göckler, Tobias 1; Albreiki, Fahed; Li, Defu; Grimm, Alisa 1; Mecklenburg, Felix 1; Urueña, Juan Manuel; Schepers, Ute 1,2; Srivastava, Samanvaya
1 Institut für Funktionelle Grenzflächen (IFG), Karlsruher Institut für Technologie (KIT)
2 Institut für Organische Chemie (IOC), Karlsruher Institut für Technologie (KIT)

Abstract:

We demonstrate the utility of block polyelectrolyte (bPE) additives to enhance
viscosity and resolve challenges with the three-dimensional (3D) printability of extrusion-based
biopolymer inks. The addition of oppositely charged bPEs to solutions of photocurable gelatin
methacryloyl (GelMA) results in complexation-driven self-assembly of the bPEs, leading to
GelMA/bPE inks that are printable at physiological temperatures, representing stark improvements
over GelMA inks that suffer from low viscosity at 37 °C, leading to low printability and poor
structural stability. The hierarchical microstructure of the self-assemblies (either jammed micelles
or 3D networks) formed by the oppositely charged bPEs, confirmed by small-angle X-ray
scattering, is attributed to the enhancements in the shear strength and printability of the GelMA/
bPE inks. Varying bPE concentration in the inks is shown to enable tunability of the rheological
properties to meet the criteria of pre- and postextrusion flow characteristics for 3D printing,
including prominent yielding behavior, strong shear thinning, and rapid recovery upon flow
cessation. Moreover, the bPE self-assemblies also contribute to the robustness of the photo-cross-
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Verlagsausgabe §
DOI: 10.5445/IR/1000169176
Veröffentlicht am 11.03.2024
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Funktionelle Grenzflächen (IFG)
Institut für Organische Chemie (IOC)
Publikationstyp Zeitschriftenaufsatz
Publikationsdatum 08.03.2024
Sprache Englisch
Identifikator ISSN: 2637-6105
KITopen-ID: 1000169176
HGF-Programm 43.33.11 (POF IV, LK 01) Adaptive and Bioinstructive Materials Systems
Erschienen in ACS Applied Polymer Materials
Verlag American Chemical Society (ACS)
Band 6
Heft 5
Seiten 2427–2441
Vorab online veröffentlicht am 21.02.2024
Nachgewiesen in Web of Science
Dimensions
Scopus
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