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Bright light therapy versus physical exercise to prevent co-occurring depression in adolescents and young adults with attention-deficit/hyperactivity disorder: a multicentre, three-arm, randomised controlled, pilot phase-IIa trial

Mayer, Jutta S. ; Kohlhas, Laura; Stermann, Jacek; Medda, Juliane; Brandt, Geva A.; Grimm, Oliver; Pawley, Adam D.; Asherson, Philip; Sanchez, Judit Palacio; Richarte, Vanesa; Bergsma, Douwe; Koch, Elena D. 1; Muntaner-Mas, Adrià; Ebner-Priemer, Ulrich W. 1; Kieser, Meinhard; Retz, Wolfgang; Ortega, Francisco B.; Colla, Michael; Buitelaar, Jan K.; ... mehr

Abstract:

Depression is common in attention-deficit/hyperactivity disorder (ADHD), but preventive behavioural interventions are lacking. This randomised controlled, pilot phase-IIa trial aimed to study a physical exercise intervention (EI) and bright light therapy (BLT)-both implemented and monitored in an individual, naturalistic setting via a mobile health (m-health) system-for feasibility of trial design and interventions, and to estimate their effects on depressive symptoms in young people with ADHD. Two hundred seven participants aged 14-45 years were randomised to 10-week add-on intervention of either BLT (10,000 lx; daily 30-min sessions) (n = 70), EI (aerobic and muscle-strengthening activities 3 days/ week) (n = 69), or treatment-as-usual (TAU) (n = 68), of whom 165 (80%) were retained (BLT: n = 54; EI: n = 52; TAU: n = 59). Intervention adherence (i.e. ≥ 80% completed sessions) was very low for both BLT (n = 13, 22%) and EI (n = 4, 7%). Usability of the m-health system to conduct interventions was limited as indicated by objective and subjective data. Safety was high and comparable between groups. Changes in depressive symptoms (assessed via observer-blind ratings, Inventory of Depressive Symptomatology) between baseline and end of intervention were small (BLT: -0.124 [95% CI: -2.219, 1.971], EI: -2.646 [95% CI: -4.777, -0.515], TAU: -1.428 [95% CI: -3.381, 0.526]) with no group differences [F(2,153) = 1.45, p = 0.2384]. ... mehr


Verlagsausgabe §
DOI: 10.5445/IR/1000170419
Veröffentlicht am 07.05.2024
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Sport und Sportwissenschaft (IfSS)
Publikationstyp Zeitschriftenaufsatz
Publikationsdatum 16.04.2024
Sprache Englisch
Identifikator ISSN: 0940-1334, 0003-9373, 0175-758X, 1433-8491
KITopen-ID: 1000170419
Erschienen in European Archives of Psychiatry and Clinical Neuroscience
Verlag Springer
Schlagwörter Attention-deficit/hyperactivity disorder; Bright light therapy; Depression; Obesity; Physical exercise; Randomised controlled trial; m-Health
Nachgewiesen in Dimensions
Scopus
Globale Ziele für nachhaltige Entwicklung Ziel 3 – Gesundheit und Wohlergehen
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